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Copyright ©2007 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jun 14, 2007; 13(22): 3128-3132
Published online Jun 14, 2007. doi: 10.3748/wjg.v13.i22.3128
Role of interventional therapy in hepatic artery stenosis and non-anastomosis bile duct stricture after orthotopic liver transplantation
Da-Bing Zhao, Hong Shan, Zai-Bo Jiang, Ming-Sheng Huang, Kang-Shun Zhu, Gui-Hua Chen, Xiao-Chun Meng, Shou-Hai Guan, Zheng-Ran Li, Jie-Sheng Qian
Da-Bing Zhao, Hong Shan, Zai-Bo Jiang, Ming-Sheng Huang, Kang-Shun Zhu, Gui-Hua Chen, Xiao-Chun Meng, Shou-Hai Guan, Zheng-Ran Li, Jie-Sheng Qian, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China
Da-Bing Zhao, The Xiangfan First Hospital, Jiefang road 75, Fancheng District, Xiangfan 441000, Hubei Province, China
Author contributions: All authors contributed equally to the work.
Supported by Organ Transplantation Center, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China
Correspondence to: Hong Shan, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China. gzshsums@public.guangzhou.gd.cn
Telephone: +86-20-87580725 Fax: +86-20-87582906
Received: February 27, 2007
Revised: March 20, 2007
Accepted: April 4, 2007
Published online: June 14, 2007
Abstract

AIM: To analyze the clinical manifestations and the effectiveness of therapy in patients with orthotopic liver transplantation (OLT)-associated hepatic artery stenosis (HAS) and non-anastomosis bile duct stricture.

METHODS: Nine cases were diagnosed as HAS and non-anastomosis bile duct stricture. Percutaneous transluminal angioplasty (PTA) was performed in four HAS cases, and expectant treatment in other five HAS cases; percutaneous transhepatic bile drainage, balloon dilation, stent placement were performed in all nine cases.

RESULTS: Diffuse intra- and extra-bile duct stricture was observed in nine cases, which was associated with bile mud siltation and biliary infection. Obstruction of the bile duct was improved obviously or removed. Life span/follow-up period was 13-30 mo after PTA of four HAS cases, 6-23 mo without PTA of other five cases.

CONCLUSION: Progressive, non-anastomosis, and diffuse bile duct stricture are the characteristic manifestations of HAS and non-anastomosis bile duct stricture after OLT. These are often associated with bile mud siltation, biliary infection, and ultimate liver failure. Interventional therapy is significantly beneficial.

Keywords: Liver transplantation; Bile duct; Postoperative complication; Stricture; Interventional therapy