Al-Moundhri MS, Al-Kindi M, Al-Nabhani M, Al-Bahrani B, Burney IA, Al-Madhani A, Ganguly SS, Tanira M. NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations. World J Gastroenterol 2007; 13(19): 2697-2702 [PMID: 17569138 DOI: 10.3748/wjg.v13.i19.2697]
Corresponding Author of This Article
Dr. Mansour S Al-Moundhri, Associate Professor & and Consultant Oncologist, Department of Medicine, College of Medicine, Sultan Qaboos University, PO Box 35, postal code 123, Muscat, Sultanate of Oman. mansours@squ.edu.om
Article-Type of This Article
Gastric Cancer
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World J Gastroenterol. May 21, 2007; 13(19): 2697-2702 Published online May 21, 2007. doi: 10.3748/wjg.v13.i19.2697
NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations
Mansour S Al-Moundhri, Mohamed Al-Kindi, Maryam Al-Nabhani, Bassim Al-Bahrani, Ikram A Burney, Ali Al-Madhani, Shyam S Ganguly, Misbah Tanira
Mansour S Al-Moundhri, Maryam Al-Nabhani, Ikram A Burney, Medical Oncology Unit, Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Sultanate of Oman
Mohamed Al-Kindi, Department of Biochemistry and Genetics, Sultan Qaboos University, Sultanate of Oman
Bassim Al-Bahrani, National Cancer Institute, Royal Hospital, Sultanate of Oman
Ali Al-Madhani, Department of Medicine, Sohar Hospital, Sultanate of Oman
Shyam S Ganguly, Department of Epidemiology and Medical Statistics, Sultan Qaboos University, Sultanate of Oman
Misbah Tanira, Department of Pharmacology, Sultan Qaboos University, Sultanate of Oman
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Mansour S Al-Moundhri, Associate Professor & and Consultant Oncologist, Department of Medicine, College of Medicine, Sultan Qaboos University, PO Box 35, postal code 123, Muscat, Sultanate of Oman. mansours@squ.edu.om
Telephone: +968-99437301 Fax: +968-24415175
Received: March 13, 2007 Revised: March 23, 2007 Accepted: March 31, 2007 Published online: May 21, 2007
Abstract
AIM: To study whether N-acetyltransferase 2 (NAT2) genotypes and phenotypes are associated with increased risk factor for gastric cancer in Omani patients and to study the clinico-pathological correlations and the prognostic significance of NAT2.
METHODS: Genomic DNA was extracted from peripheral blood of 100 gastric cancer patients and 100 control subjects. NAT2 genotyping was performed using DNA sequencing. The prognostic significance of NAT2 and other clinicopathological features was assessed by univariate and multivariate analyses.
RESULTS: We observed no significant association between NAT2 genotypes and phenotypes and gastric cancer risk. The NAT2 phenotype polymorphisms and gastric cancer risk predisposition were not modified by concomitant H pylori infection and smoking. There was no significant association between NAT2 and clinicopathological features, and NAT2 had no independent prognostic significance.
CONCLUSION: In the current study, NAT2 genotypes and phenotypes are not associated with gastric cancer risk predisposition. Moreover NAT2 phenotypes had no clinicopathological associations or prognostic significance.
