Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitis

doi:10.3748/wjg.v13.i11.1666

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Mar 21, 2007 (publication date) through Nov 3, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Research

World J Gastroenterol. Mar 21, 2007; 13(11): 1666-1671
Published online Mar 21, 2007. doi: 10.3748/wjg.v13.i11.1666

Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitis

Ichiro Hirata, Shingo Yasumoto, Ken Toshina, Takuya Inoue, Takashi Nishikawa, Naoko Murano, Mitsuyuki Murano, Fang-Yu Wang, Ken-ichi Katsu

Ichiro Hirata, Department of Gastroenterology, Fujita Health University, Japan

Shingo Yasumoto, Ken Toshina, Takuya Inoue, Takashi Nishikawa, Naoko Murano, Mitsuyuki Murano, Ken-ichi Katsu, Second Department of Internal Medicine, Osaka Medical College, Japan

Fang-Yu Wang, Department of Gastroenterology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, Jiangsu Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Ichiro Hirata, Department of Gastroenterology, Fujita Health University, 1-98 Dengakugakubo Katsukake-Cho, Toyoake, Aichi 470-1192, Japan. ihirata@fujita-hu.ac.jp

Telephone: +81-562-932345 Fax: +81-562-938300

Received: December 18, 2006
Revised: December 29, 2006
Accepted: March 6, 2007
Published online: March 21, 2007

Abstract

AIM: To evaluate the effect of pyrrolidine dithio-carbamate (PDTC; an NF-κB inhibitor) administered at low (50 mg/kg) and high (100 mg/kg) doses in suppressing colitis in mice with dextran sodium sulfate (DSS)-induced colitis.

METHODS: Mice were divided into a DSS-untreated group (normal group), DSS-treated control group, DSS+PDTC-treated groupI(low-dose group), and DSS+PDTC-treated groupII (high-dose group). In each group, the disease activity index score (DAI score), intestinal length, histological score, and the levels of activated NF-κB and inflammatory cytokines (IL-1β and TNF-α) in tissue were measured.

RESULTS: The DSS+PDTC-treated groupII exhibited suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels were significantly lower in DSS+PDTC-treated groupII.

CONCLUSION: These findings suggest that PDTC is useful for the treatment of ulcerative colitis.

Keywords: Ulcerative colitis; DSS-induced colitis; Pyrrolidine dithiocarbamate; NF-κB; Mice