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World J Gastroenterol. Feb 21, 2006; 12(7): 1110-1114
Published online Feb 21, 2006. doi: 10.3748/wjg.v12.i7.1110
Inhibitory effect of Patrinia scabiosaefolia on acute pancreatitis
Sang-Wan Seo, Cheung-Seog Park, Seung-Heon Hong, Kang-Beom Kwon, Hyoung-Chul Moon, Bong-keun Song, Kyung-Yo Kim, Young-Min Park, Ho-Joon Song, Hyung-Min Kim, Sung-Joo Park
Sang-Wan Seo, Ho-Joon Song, Sung-Joo Park, Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, South Korea
Sang-Wan Seo, Seung-Heon Hong, Department of oriental Pharmacy, College of Oriental Pharmacy, Wonkwang University, Iksan, Jeonbuk 570-749, South Korea
Kyung-Yo Kim, Bong-keun Song, Hyoung-Chul Moon, Department of Clinical laboratory, Wonkwang University Gwangju medical Center, Gwangju, Jeonnam 503-310, South Korea
Kang-Beom Kwon, Department of Physiology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, South Korea
Hyung-Min Kim, Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea
Cheung-Seog Park, Department of Microbiology, College of Medicine, Kyung Hee University, Seoul, South Korea
Young-Min Park, Department of Microbiology and Immunology, and Medical Research Institute, and Laboratory of Dendritic Cell Differentiation and Regulation, Pusan National University College of Medicine, Busan, South Korea
Co-correspondents: Hyung-Min Kim
Supported by Wonkwang University in 2005
Correspondence to: Sung-Joo Park, Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, South Korea. parksj0822@hotmail.com
Telephone: +82-63-8506844 Fax: +82-63-8562283
Received: May 23, 2005
Revised: July 2, 2005
Accepted: August 26, 2005
Published online: February 21, 2006
Abstract

AIM: To investigate the effect of Patrinia scabiosaefolia (PS) on the cholecystokinin (CCK) octapeptide- induced acute pancreatitis (AP) in rats.

METHODS: Wistar rats weighing 240-260 g were divided into three groups: (1) Normal saline-treated group; (2) treatment with PS at 100 mg/kg group, in which PS was administered orally, followed by subcutaneous administration of 75 µg/kg CCK octapeptide three times after 1, 3 and 5 h, and this whole procedure was repeated for 5 d; (3) treatment with saline group, in which the protocols were the same as in treatment group with PS. We determined the pancreatic weight/body weight ratio, the levels of pancreatic HSP60, HSP72 and the secretion of pro-inflammatory cytokines. Repeated CCK octapeptide treatment resulted in the typical laboratory findings of experimentally induced pancreatitis.

RESULTS: PS reduced the pancreatic weight/body weight ratio, the levels of serum amylase and lipase, and inhibited expressions of pro-inflammatory cytokines in the CCK octapeptide-induced AP. Furthermore, PS pretreatment increased the pancreatic levels of HSP60 and HSP72.

CONCLUSION: Pretreatment with PS has an anti-inflammatory effect on CCK octapeptide-induced AP.

Keywords: Acute pancreatitis; Patrinia scabiosaefolia; CCK octapeptide