Rapid Communication
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Dec 21, 2006; 12(47): 7699-7704
Published online Dec 21, 2006. doi: 10.3748/wjg.v12.i47.7699
Myoelectric activity and motility of the Roux limb after cut or uncut Roux-en-Y gastrojejunostomy
Ying-Mei Zhang, Xiu-Li Liu, Dong-Bo Xue, Yun-Wei Wei, Xiao-Guang Yun
Ying-Mei Zhang, Central Laboratory, First Clinical College of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Xiu-Li Liu, Department of Oncology, First Clinical College of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Dong-Bo Xue, Yun-Wei Wei, Department of General Surgery, First Clinical College of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Xiao-Guang Yun, Department of Pathology, Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Professor Xiu-Li Liu, Department of Oncology, First Clinical College of Harbin Medical University, Harbin 150001, Heilongjiang Province, China. liuxiuli928@tom.com
Telephone: +86-451-53643849
Received: September 19, 2006
Revised: November 12, 2006
Accepted: November 20, 2006
Published online: December 21, 2006
Abstract

AIM: To explore the mechanisms of uncut Roux-en-Y gastrojejunostomy, which is used to decrease the occurrence of Roux stasis syndrome.

METHODS: The changes of myoelectric activity, mechanic motility and interstitial cells of Cajal (ICC) of the Roux limb after cut or uncut Roux-en-Y gastrojejunostomy were observed.

RESULTS: When compared with the cut group, the amplitude (1.15 ± 0.15 mV vs 0.48 ± 0.06 mV, P < 0.05) and frequency (14.4 ± 1.9 cpm vs 9.5 ± 1.1 cpm, P < 0.01) of slow waves and the incidence (98.2% ± 10.4% vs 56.6% ± 6.4%, P < 0.05) and amplitude (0.58 ± 0.08 mV vs 0.23 ± 0.06 mV, P < 0.01) of spike potential of the Roux limb in the uncut group were significantly higher. The migrating myoelectric complexes (MMC) phase III duration in the uncut group was significantly prolonged (6.5 ± 1.1 min vs 4.4 ± 0.8 min, P < 0.05), while the MMC cycle obviously shortened (42.5 ± 6.8 vs 55.3 ± 8.2 min, P < 0.05). Both gastric emptying rate (65.5% ± 7.9% vs 49.3% ± 6.8%, P < 0.01) and intestinal impelling ratio (53.4% ± 7.4% vs 32.2% ± 5.4%, P < 0.01) in the uncut group were significantly increased. The contractile force index of the isolated jejunal segment in the uncut group was significantly higher (36.8 ± 5.1 vs 15.3 ± 2.2, P < 0.01), and the expression of c-kit mRNA was significantly increased in the uncut group (0.82 ± 0.11 vs 0.35 ± 0.06, P < 0.01).

CONCLUSION: Uncut Roux-en-Y gastrojejunostomy may lessen the effects of operation on myoelectric activity such as slow waves, spike potential, and MMC, decrease the impairment of gastrointestinal motility, and remarkably increase the expression of c-kit mRNA.

Keywords: Roux-en-Y anastomosis, Electromyography, Gastrointestinal motility, c-kit