Case Report
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Nov 21, 2006; 12(43): 7055-7057
Published online Nov 21, 2006. doi: 10.3748/wjg.v12.i43.7055
Pravastatin: A potential cause for acute pancreatitis
Constantine Tsigrelis, CS Pitchumoni
Constantine Tsigrelis, Department of Internal Medicine, Saint Peter’s University Hospital, Robert Wood Johnson Medical School New Brunswick, NJ, United States
CS Pitchumoni, Division of Gastroenterology, Hepatology and Clinical Nutrition, Department of Internal Medicine, Saint Peter’s University Hospital, Robert Wood Johnson Medical School, New Brunswick, NJ, United States
Author contributions: All authors contributed equally to the work.
Correspondence to: CS Pitchumoni, MD, Professor of Medicine, Chief, Division of Gastroenterology, Hepatology and Clinical Nutrition, Saint Peter’s University Hospital, Robert Wood Johnson Medical School, 254 Easton Avenue, CARES Building, New Brunswick, NJ 08903, United States. pitchumoni@hotmail.com
Telephone: +1-732-9910110 Fax: +1-732-7452980
Received: April 28, 2005
Revised: June 2, 2005
Accepted: June 9, 2005
Published online: November 21, 2006
Abstract

Acute pancreatitis (AP) secondary to drugs is un-common, with an incidence ranging from 0.3% to 2.0% of AP cases. Drug-induced AP due to statins is rare, and only 12 cases have thus far been reported. In this case report, we report a case of a 50-year-old female on pravastatin therapy for 3 d prior to developing symptoms of AP. The common etiological factors for AP were all excluded. The patient was admitted to the intensive care unit secondary to respiratory distress, though she subsequently improved and was discharged 14 d after admission. Although the incidence of drug-induced AP is low, clinicians should have a high index of suspicion for it in patients with AP due to an unknown etiology. Clinicians should be aware of the association of statins with AP. If a patient taking a statin develops abdominal pain, clinicians should consider the diagnosis of AP and conduct the appropriate laboratory and diagnostic evaluation if indicated.

Keywords: Drug-induced pancreatitis; Acute pancreatitis; Statins; Pravastatin.