Perinatal events and the risk of developing primary sclerosing cholangitis

doi:10.3748/wjg.v12.i37.6037

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Oct 7, 2006 (publication date) through Jun 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2006; 12(37): 6037-6040
Published online Oct 7, 2006. doi: 10.3748/wjg.v12.i37.6037

Perinatal events and the risk of developing primary sclerosing cholangitis

Annika Bergquist, Scott M Montgomery, Ulrika Lund, Anders Ekbom, Rolf Olsson, Stefan Lindgren, Hanne Prytz, Rolf Hultcrantz, Ulrika Broomé

Annika Bergquist, Department of Gastroenterology and Hepatology, Karolinska University Hospital, Huddinge, Karolinska Institute, Stockholm, Sweden

Scott M Montgomery, Ulrika Lund, Anders Ekbom, Clinical Epidemiology Unit, Department of Medicine Karolinska University Hospital, Solna, Karolinska Institute, Stockholm, Sweden

Rolf Olsson, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden

Stefan Lindgren, Gastroenterology and Hepatology Division, Department of Medicine, University Hospital Malmö, Sweden

Hanne Prytz, Division of Gastroenterology and Hepatology, University Hospital, Lund, Sweden

Rolf Hultcrantz, Department of Gastroenterology and Hepatology, Karolinska Institute and Hospital, Solna, Stockholm, Sweden

Correspondence to: Annika Bergquist, Department of Gastroenterology and Hepatology, Karolinska University Hospital, Huddinge, Karolinska Institute, Stockholm, Sweden. annika.bergquist@ki.se

Telephone: +46-8-58582465 Fax: +46-8-58582335

Received: July 18, 2006
Revised: July 25, 2006
Accepted: August 11, 2006
Published online: October 7, 2006

Abstract

AIM: To investigate whether perinatal events, intrauterine or postpartum, are associated with the development of primary sclerosing cholangitis (PSC) later in life.

METHODS: Birth records from 97 patients with adult PSC in Sweden were reviewed. Information on perinatal events including medications and complications during pregnancy, gestation length, birth weight and length were collected. Two control children of the same sex were selected for each subject. Conditional multiple logistic regression was used to assess associations of the perinatal measures with development of PSC.

RESULTS: No significant associations were found between gestational age, birth length, breastfeeding, and the majority of medical complications including infections or medication during pregnancy for the mothers or postpartum for the children. Vaginal bleeding and peripheral oedema showed associations with PSC, with matched odds ratios of 5.70 (95% CI, 1.13-28.83) and 2.28 (95% CI, 1.04-5.03), respectively.

CONCLUSION: The associations of vaginal bleeding and oedema with subsequent PSC cannot readily be explained, so our findings do not strongly support the hypothesis of a significant role of perinatal events as a risk for the development of PSC later in life.

Keywords: Inflammatory bowel disease, Perinatal factors, Sclerosing cholangitis