Preliminary report of hepatitis B virus genotype prevalence in Iran

doi:10.3748/wjg.v12.i32.5211

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Aug 28, 2006 (publication date) through Dec 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 28, 2006; 12(32): 5211-5213
Published online Aug 28, 2006. doi: 10.3748/wjg.v12.i32.5211

Preliminary report of hepatitis B virus genotype prevalence in Iran

Seyed-Moayed Alavian, Hossein Keyvani, Mahdi Rezaei, Neda Ashayeri, Homa Mohammad Sadeghi

Seyed-Moayed Alavian, Department of Internal Medicine, Baqiatollah Medical University, Tehran Hepatitis Center, 92 Vesal Shirazi Street, Boolvar Keshavarz, PO Box 14155/3651, Tehran, Iran

Hossein Keyvani, Department of Virology, Iran University of Medical Sciences, Hemmat Expressway, Tehran, Iran

Mahdi Rezaei, Neda Ashayeri, Homa Mohammad Sadeghi, Student’s Research Committee, Iran University of Medical Sciences, Hemmat Expressway, Tehran, Iran

Co-first-author: Seyed-Moayed Alavian

Co-correspondence: Hossein Keivani

Supported by Tehran Hepatitis Center, Keivan Virology Lab

Correspondence to: Dr. Seyed-Moayed Alavian, Associate Professor of Gastroenterology, Department of Internal Medicine, Baqiatollah Medical University, Tehran Hepatitis Center, Iran. manager@iranhepgroup.info

Telephone: +98-21-8967923

Received: November 30, 2004
Revised: January 1, 2005
Accepted: January 5, 2005
Published online: August 28, 2006

Abstract

AIM: To determine the prevalence of hepatitis B virus (HBV) genotypes in Iranian hepatitis B surface antigen (HBsAg) carriers, chronic hepatitis B and cirrhotic patients.

METHODS: A total of 109 HBsAg-positive patients were included in this study. HBV genotypes were determined by using INNO-LiPA methodology which is based on the reverse hybridization principle.

RESULTS: The distribution of patients with different stages of liver disease was as follows: 95 (86.4%) chronic hepatitis, 11 (10%) liver cirrhosis, and 3 (2.7%) inactive carrier. Of the chronic hepatitis and liver cirrhosis patients, 26.4% were HBeAg-positive while 70% were HBeAg-negative. Genotype D was the only detected type found in all patients.

CONCLUSION: Classifying HBV into genotypes has to be cost-effective and clinically relevant. Our study indicates that HBV genotype D prevails in the Mediterranean area, Near and Middle East, and South Asia. Continued efforts for understanding HBV genotype through international co-operation will reveal further virological differences of the genotypes and their clinical relevance.

Keywords: Hepatitis B virus; Genotype; Chronic Hepatitis B; Cirrhosis