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©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Aug 21, 2006; 12(31): 5094-5095
Published online Aug 21, 2006. doi: 10.3748/wjg.v12.i31.5094
Published online Aug 21, 2006. doi: 10.3748/wjg.v12.i31.5094
Obstructive jaundice leads to accumulation of oxidized low density lipoprotein in human liver tissue
Mustafa Comert, Department of Surgery, School of Medicine, Zonguldak Karaelmas University, Turkey
Yucel Ustundag, Department of Gastroenterology, School of Medicine, Zonguldak Karaelmas University, Kozlu-Zonguldak, Turkey
Ishak Ozel Tekin, Department of Immunology, School of Medicine, Zonguldak Karaelmas University, Kozlu-Zonguldak, Turkey
Banu Dogan Gun, Figen Barut, Department of Pathology, School of Medicine, Zonguldak Karaelmas University, Kozlu-Zonguldak, Turkey
Author contributions: All authors contributed equally to the work.
Correspondence to: Mustafa Comert, MD, ZKU, Arastirma ve Uygulama Hastanesi Bashekimligi, Kozlu-Zonguldak 67600, Turkey. mustafacomert@hotmail.com
Telephone: +90-372-2610159 Fax: +90-372-2610159
Received: April 25, 2006
Revised: May 16, 2006
Accepted: May 22, 2006
Published online: August 21, 2006
Revised: May 16, 2006
Accepted: May 22, 2006
Published online: August 21, 2006
Abstract
Oxidized low density lipoprotein (ox-LDL) molecule is one of the most important modified lipoproteins produced during the oxidative stress. Modified lipoproteins have been defined as being part of the immune inflammatory mechanisms in association with oxidant stress. We have reported the accumulation of ox-LDL in Balb/c mice liver after bile duct ligation previously. Here, we investigated this finding in human beings with obstructive jaundice. Our study demonstrates that obstructive jaundice results in tremendous accumulation of ox-LDL in the liver tissue of patients.