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World J Gastroenterol. Aug 7, 2006; 12(29): 4741-4744
Published online Aug 7, 2006. doi: 10.3748/wjg.v12.i29.4741
Treatment of hepatoma with liposome-encapsulated adriamycin administered into hepatic artery of rats
Dong-Sheng Sun, Jiang-Hao Chen, Rui Ling, Qing Yao, Ling Wang, Zhong Ma, Yu Li
Dong-Sheng Sun, Department of Hepatobiliary Surgery, Second Affiliated Hospital, Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Jiang-Hao Chen, Rui Ling, Qing Yao, Ling Wang, Zhong Ma, Department of Vascular and Endocrine Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710033, Shaanxi Province, China
Yu Li, Department of Cell Biology, Fourth Military Medical University, Xi’an 710033, Shaanxi Province, China
Correspondence to: Dr. Dong-Sheng Sun, Department of Hepatobiliary Surgery, Second Affiliated Hospital, Harbin Medical University, Harbin 150086, Heilongjiang Province, China. sundongsheng_1972@126.com
Telephone: +86-451-86605117
Received: March 6, 2006
Revised: March 28, 2006
Accepted: April 21, 2006
Published online: August 7, 2006
Abstract

AIM: To observe the therapeutic effects of liposome-encapsulated adriamycin (LADM) on hepatoma in comparison with adriamycin solution (FADM) and adriamycin plus blank liposome (ADM + BL) administered into the hepatic artery of rats.

METHODS: LADM was prepared by pH gradient-driven method. Normal saline, FADM (2 mg/kg), ADM+BL (2 mg/kg), and LADM (2 mg/kg) were injected via the hepatic artery in rats bearing liver W256 carcinosarcoma, which were divided into four groups randomly. The therapeutic effects were evaluated in terms of survival time, tumor enlargement ratio, and tumor necrosis degree. The difference was determined with ANOVA and Dunnett test and log rank test.

RESULTS: Compared to FADM or ADM + BL, LADM produced a more significant tumor inhibition (tumor volume ratio: 1.243 ± 0.523 vs 1.883 ± 0.708, 1.847 ± 0.661, P < 0.01), and more extensive tumor necrosis. The increased life span was prolonged significantly in rats receiving LADM compared with FADM or ADM+BL (231.48 vs 74.66, 94.70) (P < 0.05).

CONCLUSION: The anticancer efficacies of adriamycin on hepatoma can be strongly improved by liposomal encapsulation through hepatic arterial administration.

Keywords: Adriamycin; Liposome; Hepatoma