Case Report
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jul 21, 2006; 12(27): 4431-4434
Published online Jul 21, 2006. doi: 10.3748/wjg.v12.i27.4431
Transplantation of an eight-organ multivisceral graft in a patient with frozen abdomen after complicated Crohn’s disease
Andreas Pascher, Jochen Klupp, Sven Kohler, Jan M Langrehr, Peter Neuhaus
Andreas Pascher, Sven Kohler, Jan M Langrehr, Peter Neuhaus, Department of Visceral and Transplantation Surgery, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Augustenburgerplatz 1, Berlin 13353, Germany
Jochen Klupp, Exploratory Clinical Development, Novartis Pharma AG, WSJ-103.4.26, CH-4002 Basel, Switzerland
Correspondence to: Andreas Pascher, MD, Department of General and Transplantation Surgery, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Augustenburgerplatz 1, Berlin 13353, Germany. andreas.pascher@charite.de
Telephone: +49-30-450652253 Fax: +49-30-450552900
Received: August 31, 2005
Revised: September 28, 2005
Accepted: January 9, 2006
Published online: July 21, 2006
Abstract

To report an extended multivisceral transplantation (MVTx) including right kidney and ascending colon in a patient with complicated Crohn's disease (CD). A 36-year old female suffering from short bowel syndrome and frozen abdomen due to fistulizing CD after multiple abdominal operations underwent MVTx of eight organs including stomach, pancreatoduodenal complex, liver, intestine, ascending colon, right kidney, right adrenal gland, and greater omentum in November 2003. Immunosuppression consisted of alemtuzumab, tacrolimus and steroids. The patient was off parenteral nutrition by postoperative wk 3. She experienced one episode of pneumonia. The patient recovered completely and discharged 2.5 mo and was doing well 30 mo after MVTx. This is one of the very rare cases in which a complete mulitivisceral graft of eight abdominal organs was transplanted orthotopically.

Keywords: Multivisceral transplantation; Intestinal transplantation; Crohn's disease