Basic Research
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jul 7, 2006; 12(25): 3994-3998
Published online Jul 7, 2006. doi: 10.3748/wjg.v12.i25.3994
Experimental gastric dysrhythmias and its correlation with in vivo gastric muscle contractions
Jinhong Xing, Liwei Qian, Jiande Chen
Jinhong Xing, Veterans Research Foundation, Oklahoma City, Oklahoma, United States
Liwei Qian, Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas, United States
Jiande Chen, Division of Gastroenterology, University of Texas Medical Branch, Galveston, TX; and Veterans Research Foundation, Oklahoma City, Oklahoma, United States
Author contributions: All authors contributed equally to the work.
Correspondence to: Jiande Chen, PhD, 301 University Boulevard, University of Texas Medical Branch, Galveston, TX 77555-0632, United States. jianchen@utmb.edu
Telephone: +1-409-7473071 Fax: +1-409-7473084
Received: September 1, 2005
Revised: October 5, 2005
Accepted: October 9, 2005
Published online: July 7, 2006
Abstract

AIM: To study the direct correlation between gastric dysrhythmias and in vivo gastric muscle tone.

METHODS: Five healthy dogs were implanted with 4 pairs of electrodes along the greater curvature, with a strain gauge (SG) being sutured parallel to the distal electrodes (2 cm above the pylorus). Intravenous vasopressin was given to induce gastric dysrhythmia. The percentage of regular slow waves and SG energy were calculated.

RESULTS: (1) the regularity of gastric myoelectric activity (GMA) was reduced during and after infusion of vasopressin; (2) SG energy was significantly decreased during the infusion of vasopressin; (3) the decrease in SG energy was well correlated with the reduction in GMA regularity; (4) SG energy was negatively correlated with bradygastria and tachygastria.

CONCLUSION: Vasopressin inhibits gastric contractions and impairs gastric slow waves; gastric dysrhythmias are associated with the reduced antral muscle contractions, and are indicative of antral hypomotility.

Keywords: Gastric myoelectric activity; Bradygastria; Tachygastria; Gastric muscle contraction; Canine study