Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer

doi:10.3748/wjg.v12.i19.3119

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 12, Issue 19

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (3249)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series, Tables (1-3) series.

Item

Count

PDF

320

HTML

2570

Figures (1-2)

177

Tables (1-3)

182

Sum=3249

May 21, 2006 (publication date) through Nov 27, 2024

Times Cited of This Article

Times Cited (25)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Rapid Communication

World J Gastroenterol. May 21, 2006; 12(19): 3119-3122
Published online May 21, 2006. doi: 10.3748/wjg.v12.i19.3119

Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer

Shu-Qing Shi, Jian-Ting Cai, Jian-Ming Yang

Shu-Qing Shi, Jian-Ming Yang, Department of Gastroenterology, Zhejiang Provincial People’s Hospital, Hangzhou 310014, Zhejiang Province, China

Jian-Ting Cai, Department of Gastroenterology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China

Author contributions: All authors contributed equally to the work

Correspondence to: Shu-Qing Shi, Department of Gastroen-terology, Zhejiang Provincial People’s Hospital, Hangzhou 310014, Zhejiang Province, China. shp1995@126.com

Telephone: +86-0-13588735873

Received: July 18, 2005
Revised: August 5, 2005
Accepted: August 12, 2005
Published online: May 21, 2006

Abstract

AIM: To study the expression of trefoil factor 1 (TFF1) and TFF2 in precancerous condition and gastric cancer and to explore the relationship between TFFs and tumorigenesis, precancerous condition and gastric cancer.

METHODS: The expression of TFF1 and TFF2 was immunohistochemically analyzed in paraffin-embedded samples from 140 patients including 35 cases of chronic superficial gastritis (CSG), 35 cases of gastric ulcer (GU), 35 cases of chronic atrophic gastritis (CAG) and 35 cases of gastric cancer (GC).

RESULTS: TFF1 and TFF2 were located in cytoplasm of gastric mucous cells. In CSG, GU, CAG and GC, the level of TFF1 expression had a decreased tendency (P < 0.05). The expression of TFF2 was higher in GU than in CSG, but the difference was not significant. The expression of TFF2 also had a decreased tendency in GU, CAG, and GC (P < 0.05).

CONCLUSION: The reduced expression of TFF1 and TFF2 in precancerous conditions and gastric cancer may be associated with the proliferation and malignant transformation of gastric mucosa. More investigations are needed to explore the mechanism of TFFs and the relationship between TFFs and gastric cancer.

Keywords: Trefoil factor; Gastric cancer; Immunohis-tochemistry