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World J Gastroenterol. May 7, 2006; 12(17): 2770-2772
Published online May 7, 2006. doi: 10.3748/wjg.v12.i17.2770
Clinico-pathological aspects of colorectal serrated adenomas
Ashish Chandra, Adnan A Sheikh, Anton Cerar, Ian C Talbot
Ashish Chandra, Department of Pathology, St Thomas’ Hospital, Lambeth Palace Road, London, SE1 7EH, United Kingdom
Adnan A Sheikh, Department of Surgery, Royal Liverpool University Hospital, Prescot Road, Liverpool, L7 8XP, United Kingdom
Anton Cerar, Institute of Pathology, Medical Faculty, Korytkova 2, 1105 Ljubljana, Slovenia
Ian C Talbot, Academic Department of Pathology, St Mark’s and Northwick Park Hospitals NHS Trust, Harrow, Middlesex, HA1 3UJ, United Kingdom
Correspondence to: Mr Adnan A Sheikh, Department of Surgery, Royal Liverpool University Hospital, 5 Galbraith Close, Liverpool L17 9PB, United Kingdom. adnan_sheikh01@yahoo.com
Telephone: +44-151-7260806
Received: October 17, 2005
Revised: November 1, 2005
Accepted: December 27, 2005
Published online: May 7, 2006
Abstract

AIM: To study the association of colorectal serrated adenomas (SAs) with invasive carcinoma, local recurrence, synchronicity and metachronicity of lesions.

METHODS: A total of 4536 polyps from 1096 patients over an eight-year period (1987-1995) were retrospectively examined. Adenomas showing at least 50% of serrated architecture were called SAs by three reviewing pathologists.

RESULTS: Ninety-one (2%) of all polyps were called SAs, which were found in 46 patients. Invasive carcinomas were seen in 3 out of 46 (6.4%) patients, of whom one was a case of familial adenomatous polyposis (FAP). A male preponderance was noted and features of a mild degree of dysplasia were seen in majority (n=75, 83%) of serrated adenomas. Follow-up ranged 1-12 years with a mean time of 5.75 years. Recurrences of SAs were seen in 3 (6.4%) cases, synchronous SAs in 16 (34.8%) cases and metachronous SAs in 9 (19.6%) cases.

CONCLUSION: Invasive carcinoma arising in serrated adenoma is rare, accounting for 2 (4.3%) cases studied in this series.

Keywords: Serrated adenoma; Carcinoma; Polyps; Colorectum