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©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. May 7, 2006; 12(17): 2721-2729
Published online May 7, 2006. doi: 10.3748/wjg.v12.i17.2721
Published online May 7, 2006. doi: 10.3748/wjg.v12.i17.2721
A concomitant review of the effects of diabetes mellitus and hypothyroidism in wound healing
Konstantinos A Ekmektzoglou, Laboratory of Experimental Surgery and Surgical Research «N.S.Christeas», Athens School of Medicine, Athens, Greece
Georgios C Zografos, 1st University Department of General Surgery, Athens School of Medicine, Hippocration Hospital, Athens, Greece
Correspondence to: Konstantinos A Ekmektzoglou, MD, 15 Zoodohou Pigis Street, Melissia, Athens 15127, Greece. ekmektzo@hotmail.com
Telephone: +30-210-8033273 Fax: +30-210-8033273
Received: November 5, 2005
Revised: November 12, 2006
Accepted: December 26, 2005
Published online: May 7, 2006
Revised: November 12, 2006
Accepted: December 26, 2005
Published online: May 7, 2006
Abstract
This paper reviews the negative impact of diabetes mellitus or hypothyroidism on wound healing, both in experimental and clinical settings. Since both are metabolic disorders of great clinical importance, special attention is given, not only to their pathophysiology, but also to their biochemical and histological effects on tissue integrity and regeneration. Also, special focus is awarded on wound healing of the gastrointestinal tract, i.e. in intestinal anastomosis, and how these disorders can lead to wound dehiscence. Since diabetes mellitus and hypothyroidism can coexist in clinical settings, more research must be directed on their influence on wound healing, considering them as one clinical entity.
Keywords: Diabetes mellitus, Hypothyroidism, Wound healing, Anastomosis