Increase of CD4+CD25+ T cells in Smad3-/- mice

doi:10.3748/wjg.v12.i15.2455

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Apr 21, 2006 (publication date) through Feb 8, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 21, 2006; 12(15): 2455-2458
Published online Apr 21, 2006. doi: 10.3748/wjg.v12.i15.2455

Increase of CD4⁺CD25⁺ T cells in Smad3^-/- mice

Zi-Bing Wang, Yu-Fang Cui, Yu-Qing Liu, Wei Jin, Han Xu, Zhu-Jun Jiang, Ya-Xin Lu, Ying Zhang, Xiao-Lan Liu, Bo Dong

Zi-Bing Wang, Yu-Fang Cui, Wei Jin, Han Xu, Zhu-Jun Jiang, Ying Zhang, Xiao-Lan Liu, Bo Dong, Department of Immunology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China

Yu-Qing Liu, Third Affiliated Hospital of Xinxiang Medical College, Xinxiang 453003, Henan Province, China

Ya-Xin Lu, Institute of Biotechnology, Beijing 100071, China

Correspondence to: Professor Yu-Fang Cui, Department of Immunology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China. yufangc@vip.sina.com

Telephone: +86-10-66931353

Received: October 29, 2005
Revised: November 2, 2005
Accepted: November 18, 2005
Published online: April 21, 2006

Abstract

AIM: To investigate the changes of lymphocyte subpopulations, especially CD4⁺CD25⁺ T regulatory cells in Smad3^-/- mice.

METHODS: Hematological changes and changes of lymphocyte subpopulations were detected in Smad3^-/- mice using cell counter and flow cytometry, respectively, and compared to their littermate controls.

RESULTS: The numbers of neutrophils and lymphocytes in peripheral blood were significantly increased in Smad3^-/- mice compared to littermate controls. CD19⁺ expressing cells in blood and spleen, and CD8⁺ T cells in thymus were all markedly decreased in Smad3^-/- mice. More important, Smad3^-/- mice had an increased population of CD4⁺CD25⁺ T cells in peripheral lymphoid tissues, including thymus, spleen, and lymph nodes.

CONCLUSION: These observations suggest that the changes of lymphocyte subpopulations might play a role in susceptibility to inflammation of Smad3^-/- mice.

Keywords: CD4⁺CD25⁺ T cells; Lymphocyte subpopulation; SMAD3; TGF-β signaling