Colorectal Cancer
Copyright ©2005 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2005; 11(9): 1287-1291
Published online Mar 7, 2005. doi: 10.3748/wjg.v11.i9.1287
Tumor angiogenesis and dynamic CT in colorectal carcinoma: Radiologic-pathologic correlation
Zi-Ping Li, Quan-Fei Meng, Can-Hui Sun, Da-Sheng Xu, Miao Fan, Xu-Feng Yang, Dong-Ying Chen
Zi-Ping Li, Quan-Fei Meng, Can-Hui Sun, Da-Sheng Xu, Miao Fan, Xu-Feng Yang, Department of Radiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
Dong-Ying Chen, Department of Pathology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
Author contributions: All authors contributed equally to the work.
Supported by the Medical Science Foundation of Guangdong Province, No. A2002185
Correspondence to: Dr. Zi-Ping Li, Department of Radiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China. liziping163@163.net
Telephone: +86-20-87335415 Fax: +86-20-87750632
Received: August 18, 2004
Revised: August 21, 2004
Accepted: November 19, 2004
Published online: March 7, 2005
Abstract

AIM: To investigate the correlation between microvessel density and spiral CT perfusion imaging in colorectal carcinoma.

METHODS: Thirty-seven patients, with histologically proven colorectal carcinoma, underwent water enema spiral CT scan. The largest axial surface of the primary tumor was searched on unenhanced spiral CT images. At this level, the enhanced dynamic scan series was acquired. Time-density curves (TDC) were created from the region of interest drawn over the tumor, target artery by Toshiba Xpress/SX spiral CT with perfusion functional software. Then the perfusion was calculated. Microvessel density (MVD) was evaluated using immunohistochemical staining of surgical specimens with anti-CD34, and then MVD was correlated with perfusion.

RESULTS: MVD of colorectal carcinomas was 33.11-173.44, mean 87.28, and perfusion was 15.60-64.80 mL/min/ 100 g, mean 39.74 mL/min/100 g. MVD and perfusion were not associated with invasive depth, metastasis and disease stage, and they all decreased with increasing Dukes’ stage, but no significant correlation was found between them (r = 0.18, P = 0.29).

CONCLUSION: There is no significant correlation between MVD and perfusion. Neovascularizaton and perfusion are highly presented in early colorectal carcinoma. CT perfusion imaging may be more suited for assessing tumorigenesis in colorectal carcinoma than histological MVD technique.

Keywords: Microvessel density; CT; Colorectal carcinoma