Helicobacter pylori infection in hemodialysis patients: Susceptibility to amoxicillin and clarithromycin

doi:10.3748/wjg.v11.i6.842

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Feb 14, 2005 (publication date) through Jul 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 14, 2005; 11(6): 842-845
Published online Feb 14, 2005. doi: 10.3748/wjg.v11.i6.842

Helicobacter pylori infection in hemodialysis patients: Susceptibility to amoxicillin and clarithromycin

Selim Aydemir, Sedat Boyacioglu, Gurden Gur, Muge Demirbilek, Fusun Kamber Can, Murat Korkmaz, Ugur Yilmaz

Selim Aydemir, Department of Gastroenterology, Zonguldak Karaelmas University Faculty of Medicine, 67800, Zonguldak, Turkey

Sedat Boyacioglu, Gurden Gur, Murat Korkmaz, Ugur Yilmaz, Department of Gastroenterology, Baskent University Faculty of Medicine, 06000, Ankara, Turkey

Muge Demirbilek, Fusun Kamber Can, Department of Clinical Microbiology, Baskent University Faculty of Medicine, 06000, Ankara, Turkey

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Selim Aydemir, Department of Gastroenterology, Zonguldak Karaelmas University Faculty of Medicine, 67800, Zonguldak, Turkey. selimaydemir@hotmail.com

Telephone: +90-372-2576169

Received: July 5, 2004
Revised: July 7, 2004
Accepted: October 13, 2004
Published online: February 14, 2005

Abstract

AIM: To evaluate susceptibility of Helicobacter pylori to amoxicillin and clarithromycin in end-stage renal disease (ESRD) patients and non-uremic controls.

METHODS: The subjects with dyspeptic complaints were 33 ESRD patients and 46 age- and sex-matched non-uremic controls who exhibited H pylori on antral biopsy specimens. The two groups were age and sex matched. The H pylori strains’ pattern of susceptibility to amoxicillin and clarithromycin was investigated with the agar dilution technique.

RESULTS: None of the H pylori strains from either group showed resistance to amoxicillin with the agar dilution method. Twelve (36.4%) of the ESRD group strains and 7 (15.2%) of the control group strains showed resistance to clarithromycin, and this difference was statistically significant (P<0.05).

CONCLUSION: Resistance to amoxicillin does not appear to be an important problem in H pylori-infected ESRD and non-uremic patients in our region. In contrast, the rates of resistance to clarithromycin are high, particularly in the ESRD population.

Keywords: Helicobacter pylori, Chronic renal failure, Antibiotic resistance, Clarithromycin, Amoxicillin