Possible involvement of leptin and leptin receptor in developing gastric adenocarcinoma

doi:10.3748/wjg.v11.i48.7666

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 11, Issue 48

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (3195)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series, Tables (1-3) series.

Item

Count

PDF

322

HTML

2506

Figures (1-2)

180

Tables (1-3)

187

Sum=3195

Dec 28, 2005 (publication date) through Nov 25, 2024

Times Cited of This Article

Times Cited (26)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Rapid Communication

World J Gastroenterol. Dec 28, 2005; 11(48): 7666-7670
Published online Dec 28, 2005. doi: 10.3748/wjg.v11.i48.7666

Possible involvement of leptin and leptin receptor in developing gastric adenocarcinoma

Lei Shen, He-Sheng Luo, Zhi-Xiang Shen, Liang Zhao

Liang Zhao, Zhi-Xiang Shen, He-Sheng Luo, Lei Shen, Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, Hubei Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Liang Zhao, MD, Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, Hubei Province, China. airman-zhao@tom.com

Telephone: +86-27-88041919-2135

Received: January 31, 2005
Revised: April 2, 2005
Accepted: April 11, 2005
Published online: December 28, 2005

Abstract

AIM: To investigate the expression of leptin and leptin receptor (ob-R) in intestinal-type gastric cancer and precancerous lesions, and to explore the possible mechanism and role of the leptin system in developing intestinal-type gastric adenocarcinoma.

METHODS: Immunohistochemistry was performed to examine the expression of leptin and leptin receptor in archival samples of gastric adenocarcinoma and preneoplastic lesions, including intestinal metaplasia and mild to severe gastric epithelial dysplasia. Positive staining was identified and percentage of positive staining was graded.

RESULTS: Dual expression of leptin and leptin receptor were detected in 80% (16/20) intestinal metaplasia, 86.3% (25/30) mild gastric epithelial dysplasia, 86.7% (26/30) moderate gastric epithelial dysplasia, 93.3% (28/30) severe gastric epithelial dysplasia, 91.3% (55/60) intestinal-type gastric adenocarcinoma and 30.0% (9/30) diffuse-type gastric carcinoma. The percentage of dual expression of leptin and leptin receptor in intestinal-type gastric adenocarcinoma was significantly higher than that in diffuse-type gastric adenocarcinoma (χ² = 37.022, P<0.01).

CONCLUSION: Our results indicate the presence of an autocrine loop of leptin system in the development of intestinal-type gastric adenocarcinoma.

Keywords: Leptin; Leptin receptor (ob-R); Intestinal-type gastric adenocarcinoma; Intestinal metaplasia; Gastric epithelial dysplasia