Corleto VD, Zykaj E, Mercantini P, Pilozzi E, Rossi M, Carnuccio A, Giulio ED, Ziparo V, Fave GD. Is colonoscopy sufficient for colorectal cancer surveillance in all HNPCC patients? World J Gastroenterol 2005; 11(47): 7541-7544 [PMID: 16437731 DOI: 10.3748/wjg.v11.i47.7541]
Corresponding Author of This Article
Vito D Corleto, MD, Department of Digestive and Liver Diseases, II School of Medicine, University “La Sapienza”, Sant’Andrea Hospital, Via di Grottarossa 1035-1037, 00189 Rome, Italy. corleto@bce.uniroma1.it
Article-Type of This Article
Case Report
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World J Gastroenterol. Dec 21, 2005; 11(47): 7541-7544 Published online Dec 21, 2005. doi: 10.3748/wjg.v11.i47.7541
Is colonoscopy sufficient for colorectal cancer surveillance in all HNPCC patients?
Vito D Corleto, Ermira Zykaj, Paolo Mercantini, Emanuela Pilozzi, Michele Rossi, Antonella Carnuccio, Emilio Di Giulio, Vincenzo Ziparo, Gianfranco Delle Fave
Vito D Corleto, Department of Digestive and Liver Diseases, II School of Medicine, University “La Sapienza”, Centro Ricerche S. Pietro FBF, Rome, Italy
Ermira Zykaj, Antonella Carnuccio, Emilio Di Giulio, Gianfranco Delle Fave, Department of Digestive and Liver Diseases, II School of Medicine, University “La Sapienza”, Rome, Italy
Paolo Mercantini, Vincenzo Ziparo, Department of Surgery, II School of Medicine, University “La Sapienza”, Rome, Italy
Emanuela Pilozzi, Department of Pathology, II School of Medicine, University “La Sapienza”, Rome, Italy
Michele Rossi, Department of Radiology, II School of Medicine, University “La Sapienza”, Rome, Italy
Author contributions: All authors contributed equally to the work.
Supported by Ricerche Ateneo 2004 n. C26A044873, University “La Sapienza”, Rome, and PRIN 2003, n. 2003063877_002
Correspondence to: Vito D Corleto, MD, Department of Digestive and Liver Diseases, II School of Medicine, University “La Sapienza”, Sant’Andrea Hospital, Via di Grottarossa 1035-1037, 00189 Rome, Italy. corleto@bce.uniroma1.it
Telephone: +39-06-80345289 Fax: +39-06-33251278
Received: April 7, 2005 Revised: April 23, 2005 Accepted: April 26, 2005 Published online: December 21, 2005
Abstract
A 34-year-old male with hereditary non-polyposis colon cancer with a mutation in hMSH2 line is reported. Despite regular colonoscopic follow-up, he developed cecal cancer involving the extraluminal area. Due to sub-occlusive symptoms, the patient was submitted to further colonoscopy, however with no clear evidence of neoplasia. Thin slice multiplanar reconstruction computed tomography CT scan performed thereafter revealed a transmural mass 2.5 cm in size localized near the cecal valve. Discussion is made on the reliability of colonoscopic examinations as well as the need for further investigations in the follow-up of patients at very high risk of right-sided colon cancer, such as male hMSH2 carrier affected by hereditary non-polyposis colon cancer.
