Evaluation of liver tissue by polymerase chain reaction for hepatitis B virus in patients with negative viremia

doi:10.3748/wjg.v11.i43.6853

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2005; 11(43): 6853-6857
Published online Nov 21, 2005. doi: 10.3748/wjg.v11.i43.6853

Evaluation of liver tissue by polymerase chain reaction for hepatitis B virus in patients with negative viremia

Fouad Thakeb, Magdy El-Serafy, Soheir Zakaria, Bahaa Monir, Sahar Lashin, Raghda Marzaban, Mostafa El-Awady

Fouad Thakeb, Magdy El-Serafy, Soheir Zakaria, Tropical Medicine Department, Cairo University, Egypt

Bahaa Monir, Sahar Lashin, Raghda Marzaban, Pathology Department, Cairo University, Egypt

Mostafa El-Awady, Department of Biomedical Technology, National Research Center, Cairo, Egypt

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr Mostafa K El-Awady, Department of Biomedical Technology, National Research Center, Tahrir Street, Dokki, Cairo, Egypt. mkawady@yahoo.com

Telephone: +20123132640

Received: February 4, 2005
Revised: April 1, 2005
Accepted: April 10, 2005
Published online: November 21, 2005

Abstract

AIM: To assess the clinical significance of Hepatitis B virus (HBV) DNA localization in the liver tissue of patients with positive HBsAg and negative viremia.

METHODS: HBV virological parameters of 33 HBsAg positive chronic hepatitis patients, including seromarkers and HBV DNA amplification in both sera and liver biopsies, were evaluated.

RESULTS: Ten patients had negative viremia and positive HBV DNA in their liver biopsies. Most of them had HBeAg-negative/HBeAb-positive chronic hepatitis. Their liver biochemical and histopathological profiles were different from the viremic patients. Their disease pattern was designated as “hepatitis B in situ”.

CONCLUSION: Hepatitis B in situ is a consequential entity which can be missed in clinical practice. It is a new clinical pattern of chronic HBV infection that considers HBV in liver biopsy and adds a new indication for antiviral therapy.

Keywords: Hepatitis B in situ; Antiviral therapy; HBV DNA; Chronic hepatitis