Helicobacter Pylori
Copyright ©2005 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2005; 11(43): 6745-6750
Published online Nov 21, 2005. doi: 10.3748/wjg.v11.i43.6745
Soluble adhesion molecules ICAM-1, VCAM-1, P-selectin in children with Helicobacter pylori infection
Elzbieta Maciorkowska, Maciej Kaczmarski, Anatol Panasiuk, Katarzyna Kondej-Muszynska, Andrzej Kemonai
Elzbieta Maciorkowska, Department of Pediatric Nursing, Medical University of Bialystok, Poland
Katarzyna Kondej-Muszynska, Maciej Kaczmarski, 3rd Department of Children’s Diseases, Medical University of Bialystok, Poland
Anatol Panasiuk, Department of Infectious Diseases, Medical University of Bialystok, Poland
Andrzej Kemonai, Department of Pathomorphology, Medical University of Bialystok, Poland
Author contributions: All authors contributed equally to the work.
Correspondence to: Elzbieta Maciorkowska, MD, Department of Pediatric Nursing, Medical University of Bialystok, Waszyngtona Str., 15, 15-274 Bialystok, Poland. emaciorkowska@o2.pl
Telephone: +48-85-7-450-565 Fax: +48-85-7-450-568
Received: March 1, 2005
Revised: April 26, 2005
Accepted: April 30, 2005
Published online: November 21, 2005
Abstract

AIM: To assess the sICAM-1, sVCAM-1, and sP-selectin levels in children with Helicobacter pylori (H pylori) infection and to evaluate their significance for the morphological changes found in gastric mucosa.

METHODS: The study included 106 children: 59 children (55.7%) with chronic gastritis and positive IgG against H pylori, 29 children (27.3%) after previous H pylori infection without the bacterium colonization but with positive IgG against H pylori, and 18 children (17%) with functional disorders of the gastrointestinal system but with normal IgG against H pylori. Endoscopic and histopathological evaluation of gastric mucosa was performed based on the Sydney System classification. The evaluation of sP-selectin, sICAM-1, sVCAM-1 levels in the sera of children was carried out using ELISA test.

RESULTS: The assessment of gastritis activity degrees indicated statistically significant values in the antrum and corpus (P<0.001) of children examined. Serum sVCAM-1 levels were higher in group with gastritis due to H pylori infection than in group without infection and differed statistically (P<0.05). Serum sVCAM-1 levels proved to be the highest among other adhesive molecules in infected children and decreased after eradication of H pylori. Serum sICAM-1 levels were similar in all examined groups. Serum sP-selectin levels were similar in children with and without H pylori infection.

CONCLUSION: Assessment of adhesive molecules (sP-selectin, sICAM-1, sVCAM-1) in the sera of children with active H pylori infection can show the participation of sVCAM-1 in the pathogenesis of gastric mucosal inflammation. sP-selectin and sICAM-1 concentrations in the sera of children with H pylori infection after eradication cannot reveal any significant differences as compared to healthy children.

Keywords: sVCAM-1; sICAM-1; sP-selectin; Helicobacter pylori