Preoperative sorting of circulating T lymphocytes in patients with esophageal squamous cell carcinoma: Its prognostic significance

doi:10.3748/wjg.v11.i42.6689

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2005; 11(42): 6689-6693
Published online Nov 14, 2005. doi: 10.3748/wjg.v11.i42.6689

Preoperative sorting of circulating T lymphocytes in patients with esophageal squamous cell carcinoma: Its prognostic significance

Tadahiro Nozoe, Yoshihiko Maehara, Keizo Sugimachi

Tadahiro Nozoe, Department of Surgery, Fukuoka Higashi Medical Center, Koga, Japan

Yoshihiko Maehara, Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Keizo Sugimachi, Kyushu Central Hospital

Author contributions: All authors contributed equally to the work.

Correspondence to: Tadahiro Nozoe, Department of Surgery, Fukuoka Higashi Medical Center, 1-1-1, Chidori, Koga 811-3195, Japan. ntvb@med.uoeh-u.ac.jp

Telephone: Fax: +81-92-943-8775

Received: April 7, 2004
Revised: February 12, 2005
Accepted: February 15, 2005
Published online: November 14, 2005

Abstract

AIM: To elucidate the immunologic parameters for the outcome of patients with malignant tumors, especially esophageal squamous cell carcinoma (ESCC) associated with high malignant potential.

METHODS: Clinicopathologic features were compared between patients with lower and higher CD4 and CD8 values as well as CD4/CD8 ratio in peripheral blood.

RESULTS: The survival rate of patients with higher CD4 value was significantly better than that in patients with lower CD4 value (P = 0.039). The survival rate of patients with higher CD8 value was significantly worse than that of patients with lower CD8 value (P = 0.026). Similarly, the survival rate of patients with higher CD4/CD8 ratio was significantly better than that of patients with lower CD4/CD8 ratio (P = 0.042). Additionally, multivariate analysis demonstrated that lower CD8 and lower CD4/CD8 ratio were factors independently associated with worse prognosis of patients.

CONCLUSION: All the immunologic parameters can predict the outcome of patients with ESCC.

Keywords: Lymphocyte sub-population; Esophagus; Squamous cell carcinoma; Prognostic indicator