Seo SW, Koo HN, An HJ, Kwon KB, Lim BC, Seo EA, Ryu DG, Moon G, Kim HY, Kim HM, Hong SH. Taraxacum officinale protects against cholecystokinin-induced acute pancreatitis in rats. World J Gastroenterol 2005; 11(4): 597-599 [PMID: 15641154 DOI: 10.3748/wjg.v11.i4.597]
Corresponding Author of This Article
Dr. Seung-Heon Hong, Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 570-749, South Korea. jooklim@wonkwang.ac.kr
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Brief Reports
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World J Gastroenterol. Jan 28, 2005; 11(4): 597-599 Published online Jan 28, 2005. doi: 10.3748/wjg.v11.i4.597
Taraxacum officinale protects against cholecystokinin-induced acute pancreatitis in rats
Sang-Wan Seo, Hyun-Na Koo, Hyo-Jin An, Kang-Beom Kwon, Byung-Cheal Lim, Eun-A Seo, Do-Gon Ryu, Goo Moon, Hong-Yeoul Kim, Hyung-Min Kim, Seung-Heon Hong
Sang-Wan Seo, Hyun-Na Koo, Hyo-Jin An, Hyung-Min Kim, Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea
Sang-Wan Seo, Hyo-Jin An, Seung-Heon Hong, Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk, South Korea
Kang-Beom Kwon, Byung-Cheal Lim, Do-Gon Ryu, Goo Moon, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, South Korea
Eun-A Seo, Department of Food and Nutrition, School of Human Environmental Science, Wonkwang University, Jeonbuk, South Korea
Hong-Yeoul Kim, Institute of Oriental Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea
Author contributions: All authors contributed equally to the work.
Supported by Wonkwang University in 2003
Correspondence to: Dr. Seung-Heon Hong, Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 570-749, South Korea. jooklim@wonkwang.ac.kr
Telephone: +82-63-8506805 Fax: +82-63-8433421
Received: April 4, 2004 Revised: April 8, 2004 Accepted: May 15, 2004 Published online: January 28, 2005
Abstract
AIM: Taraxacum officinale (TO) has been frequently used as a remedy for inflammatory diseases. The aim of this study was to investigate the effect of TO on cholecystokinin (CCK)-octapeptide-induced acute pancreatitis in rats.
METHODS: TO at 10 mg/kg was orally administered, followed by 75 μg/kg CCK octapeptide injected subcutaneously three times after 1, 3 and 5 h. This whole procedure was repeated for 5 d. We determined the pancreatic weight/body weight ratio, the levels of pancreatic HSP60 and HSP72, and the secretion of pro-inflammatory cytokines. Repeated CCK octapeptide treatment resulted in typical laboratory and morphological changes of experimentally-induced pancreatitis.
RESULTS: TO significantly decreased the pancreatic weight/body weight ratio in CCK octapeptide-induced acute pancreatitis. TO also increased the pancreatic levels of HSP60 and HSP72. Additionally, the secretion of IL-6 and TNF-α decreased in the animals treated with TO.
CONCLUSION: TO may have a protective effect against CCK octapeptide-induced acute pancreatitis.
