Inhibitory effects of polysaccharides isolated from Phellinus gilvus on benzo(a)pyrene-induced forestomach carcinogenesis in mice

doi:10.3748/wjg.v11.i4.577

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Jan 28, 2005 (publication date) through Nov 8, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 28, 2005; 11(4): 577-579
Published online Jan 28, 2005. doi: 10.3748/wjg.v11.i4.577

Inhibitory effects of polysaccharides isolated from Phellinus gilvus on benzo(a)pyrene-induced forestomach carcinogenesis in mice

Jae-Sung Bae, Kwang-Ho Jang, Hyunee Yim, Seung-Chun Park, Hee-Kyung Jin

Jae-Sung Bae, Kwang-Ho Jang, Seung-Chun Park, Hee-Kyung Jin, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea

Hyunee Yim, Department of Pathology, Ajou University School of Medicine, Suwon, Republic of Korea

Author contributions: All authors contributed equally to the work.

Supported by grant R08-2003-000-10120-0 from the Basic Research Program of the Korea Science & Engineering Foundation

Correspondence to: Dr. Hee-Kyung Jin, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea. hkjin@mail.knu.ac.kr

Telephone: +82-53-950-5966 Fax: +82-53-950-5955

Received: May 10, 2004
Revised: May 14, 2004
Accepted: June 18, 2004
Published online: January 28, 2005

Abstract

AIM: Although polysaccharides from Phellinus mushrooms are a well-known material with anti-tumor properties, there is no information about the effect of polysaccharides from Phellinus gilvus (PG) on tumor. The modulating effect of polysaccharides isolated from PG on the benzo(a)pyrene (BaP)-induced forestomach carcinogenesis in ICR female mice was investigated in this study.

METHODS: A forestomach carcinogenesis model was established in 40 ICR female mice receiving oral administration of BaP for 4 wk. The mice were randomly assigned to 4 groups (10 each). The mice in each group were treated with sterile water or PG for 4 and 8 wk (SW4, PGW4, SW8, and PGW8 groups). Eight or 12 wk after the first dose of BaP, forestomachs were removed for histopathological and RT-PCR analysis.

RESULTS: In histopathological changes and RT-PCR analysis, sterile water-treated mice showed significant hyperplasia of the gastric mucosa with a significantly increased expression of mutant p53 mRNA compared to mice treated with PG for 8 wk.

CONCLUSION: Polysaccharides isolated from PG may inhibit BaP-induced forestomach carcinogenesis in mice bydown-regulating mutant p53 expression.

Keywords: Forestomach carcinogenesis; Phellinus gilvus; Polysaccharides; p53 Gene