Méndez-Sánchez N, Bermejo-Martínez LB, Viñals Y, Chavez-Tapia NC, Graff IV, Ponciano-Rodríguez G, Ramos MH, Uribe M. Serum leptin levels and insulin resistance are associated with gallstone disease in overweight subjects. World J Gastroenterol 2005; 11(39): 6182-6187 [PMID: 16273647 DOI: 10.3748/wjg.v11.i39.6182]
Corresponding Author of This Article
Nahum Méndez-Sánchez, MD, PhD, Departments of Biomedical Research, Gastroenterology and Liver Unit, Medica Sur Clinic and Foundation, Puente de Piedra 150, Col. Toriello Guerra, Mexico City, Mexico. nmendez@medicasur.org.mx
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Brief Reports
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World J Gastroenterol. Oct 21, 2005; 11(39): 6182-6187 Published online Oct 21, 2005. doi: 10.3748/wjg.v11.i39.6182
Serum leptin levels and insulin resistance are associated with gallstone disease in overweight subjects
Nahum Méndez-Sánchez, Luisa B Bermejo-Martínez, Yolanda Viñals, Norberto C Chavez-Tapia, Irina Vander Graff, Guadalupe Ponciano-Rodríguez, Martha H Ramos, Misael Uribe
Nahum Méndez-Sánchez, Yolanda Viñals, Norberto C Chavez-Tapia, Irina Vander Graff, Martha H Ramos, Misael Uribe, Departments of Biomedical Research and Gastroenterology and Liver Unit, Medica Sur Clinic and Foundation, Mexico City, Mexico
Luisa B Bermejo-Martínez, Clinical Research Center, National Institute of Perinatology. Mexico City, Mexico
Guadalupe Ponciano-Rodríguez, Faculty of Medicine, National Autonomous University of Mexico (UNAM). Mexico City, Mexico
Author contributions: All authors contributed equally to the work.
Supported by the National Council of Science and Technology of Mexico (CONACYT) and The Ministry of Health (SSA), Mexico project No. M0059-M9602 (NM-S and MU)
Correspondence to: Nahum Méndez-Sánchez, MD, PhD, Departments of Biomedical Research, Gastroenterology and Liver Unit, Medica Sur Clinic and Foundation, Puente de Piedra 150, Col. Toriello Guerra, Mexico City, Mexico. nmendez@medicasur.org.mx
Received: January 5, 2005 Revised: June 1, 2005 Accepted: June 2, 2005 Published online: October 21, 2005
Abstract
AIM: To establish an association between the serum leptin levels and the development of gallstone disease (GD).
METHODS: We carried out a non-matched case-controlled study in a university hospital in Mexico City. Two hundred and eighty-seven subjects were included: 97 cases with gallstones and 190 controls. Body mass index (BMI), fasting plasma leptin, insulin, serum lipid, and lipoprotein levels were measured. Insulin resistance was calculated by homeostasis model assessment (HOMA-IR). Unconditional logistic regression analysis (univariate and multivariate) stratified by BMI was used to calculate the risk of GD.
RESULTS: The multivariate conditional regression analysis revealed a model for those patients with BMI <30. The selected variables in the model were HOMA-IR index with OR = 1.31, P = 0.02 and leptin higher than median with OR = 2.11, P = 0.05. In the stratum of BMI ≥30, we did not find a useful model.
CONCLUSION: We concluded that insulin resistance and the development of GD appears to be associated with serum leptin levels in subjects with overweight, but not in obese subjects with similar metabolic profiles.
