Brief Reports
Copyright ©The Author(s) 2005. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 7, 2005; 11(37): 5905-5909
Published online Oct 7, 2005. doi: 10.3748/wjg.v11.i37.5905
Primary early-stage intestinal and colonic non-Hodgkin’s lymphoma: Clinical features, management, and outcome of 37 patients
Shu-Lian Wang, Zhong-Xing Liao, Xin-Fan Liu, Zi-Hao Yu, Da-Zhong Gu, Tu-Nan Qian, Yong-Wen Song, Jing Jin, Wei-Hu Wang, Ye-Xiong Li
Shu-Lian Wang, Xin-Fan Liu, Zi-Hao Yu, Da-Zhong Gu, Tu-Nan Qian, Yong-Wen Song, Jing Jin, Wei-Hu Wang, Ye-Xiong Li, Department of Radiation Oncology, Cancer Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 10021, China
Zhong-Xing Liao, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston 77030, TX, USA
Author contributions: All authors contributed equally to the work.
Correspondence to: Shu-Lian Wang, MD, Department of Radiation Oncology, Cancer Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 17 Panjiayuan nanli, Chaoyang District, Beijing, 100021, China. slwang@mdanderson.org
Telephone: +86-10-87788122 Fax: +86-10-67706153
Received: January 3, 2005
Revised: February 13, 2005
Accepted: February 18, 2005
Published online: October 7, 2005
Abstract

AIM: To analyze the clinical features, management, and outcome of treatment of patients with primary intestinal and colonic non-Hodgkin’s lymphoma (PICL).

METHODS: A retrospective study was performed in 37 patients with early-stage PICL who were treated in our hospital from 1958 to 1998. Their clinical features, management, and outcome were assessed. Prognostic factors for survival were analyzed by univariate analysis using the Kaplan-Meier product-limit method and log-rank test.

RESULTS: Twenty-five patients presented with Ann Arbor stage I PICL and 12 with Ann Arbor stage II PICL. Thirty-five patients underwent surgery (including 31 with complete resection), 22 received postoperative chemotherapy or radiotherapy or both. Two patients with rectal tumors underwent biopsy and chemotherapy with or without radiotherapy. The 5- and 10-year overall survival (OS) rates were 51.9% and 44.5%. The corresponding disease-free survival (DFS) rates were 42.4% and 37.7%. In univariate analysis, multiple-modality treatment was associated with a better DFS rate compared to single treatment (P = 0.001). While age, tumor size, tumor site, stage, histology, or extent of surgery were not associated with OS and DFS, use of adjuvant chemotherapy significantly improved DFS (P = 0.031) for the 31 patients who underwent complete resection. Additional radiotherapy combined with chemo-therapy led to a longer survival than chemotherapy alone in six patients with gross residual disease after surgery or biopsy.

CONCLUSION: Combined surgery and chemotherapy is recommended for treatment of patients with PICL. Additional radiotherapy is needed to improve the outcome of patients who have gross residual disease after surgery.

Keywords: Intestinal neoplasm; Colonic neoplasm; Non-Hodgkin’s lymphoma; Surgery; Chemotherapy; Radiotherapy