Polymorphism of CYPIA1 and GSTM1 genes associated with susceptibility of gastric cancer in Shandong Province of China

doi:10.3748/wjg.v11.i37.5757

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Gastric Cancer

World J Gastroenterol. Oct 7, 2005; 11(37): 5757-5762
Published online Oct 7, 2005. doi: 10.3748/wjg.v11.i37.5757

Polymorphism of CYPIA1 and GSTM1 genes associated with susceptibility of gastric cancer in Shandong Province of China

Hao Li, Xue-Liang Chen, Hui-Qing Li

Hao Li, Xue-Liang Chen, the Center of Tumour Treatment, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China

Hui-Qing Li, the Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan 250062, Shandong Province, China

Author contributions: All authors contributed equally to the work.

Supported by the Association of Science and Technology of Shandong Province, No. Y97C21057

Correspondence to: Hao Li, the Center of Tumour Treatment, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China. haoli611@yahoo.com

Telephone: +86-531-82169873

Received: January 14, 2005
Revised: February 23, 2005
Accepted: February 28, 2005
Published online: October 7, 2005

Abstract

AIM: To explore whether polymorphisms of the CYPIA1 and GSTM1 genes are associated with susceptibility of stomach cancer.

METHODS: A total of 102 stomach cancer cases and 62 healthy persons were diagnosed by pathology in 1998-2000 in the Qilu Hospital of Shandong University. Gene polymorphisms were detected by the PCR using sequence-specific primers. Data analysis of the case-control study was carried out using the unconditional logistic method.

RESULTS: After adjustment for age, sex, educational levels, and occupation, the risk factors for stomach cancer were shown to be smoking, Helicobacter pylori (H pylori), and presence of the CYPIM G/G and GSTM1 O/O genotypes. Interaction was observed between the combined genotypes of either CYPIA1 G/G and GSTM1 O/O or H pylori infection, or GSTM1 O/O and H pylori infection or smoking.

CONCLUSION: Polymorphisms of the CYPIA1 and GSTM1 genes, H pylori infection and smoking are related to susce-ptibility to stomach cancer.

Keywords: Stomach cancer; CYPIA1; GSTM1; Polymorphism