B7 molecule mRNA expression in colorectal carcinoma

doi:10.3748/wjg.v11.i36.5655

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Sep 28, 2005 (publication date) through Nov 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Sep 28, 2005; 11(36): 5655-5658
Published online Sep 28, 2005. doi: 10.3748/wjg.v11.i36.5655

B₇ molecule mRNA expression in colorectal carcinoma

Ju-Xiang Xiao, Pei-Song Bai, Bao-Chang Lai, Li Li, Juan Zhu, Yi-Li Wang

Ju-Xiang Xiao, Pei-Song Bai, Li Li, Juan Zhu, Department of Oncology, First Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China

Bao-Chang Lai, Yi-Li Wang, Institute for Cancer research, School of Life Science and Technology of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China

Author contributions: All authors contributed equally to the work.

Supported by the National Natural Science Foundation of China, No. 30370549

Correspondence to: Dr. Ju-Xiang Xiao, Department of Oncology, First Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China. xiao_juxiang@yahoo.com

Telephone: +86-29-85324068 Fax: +86-29-85237369

Received: May 13, 2005
Revised: June 2, 2005
Accepted: June 6, 2005
Published online: September 28, 2005

Abstract

AIM: To observe the status of tumor-associated B₇ molecule mRNA expression in human colorectal cancer tissue by in situ hybridization.

METHODS: The mRNA expression patterns of cancer-associated B_7-1,B₇H₁,B₇H₂,ICOS in 22 specimens of human colorectal cancer tissue were monitored by in situ hybridization (ISH) with digoxin-labeled oligonucleotide probes.

RESULTS: B_7-1,B₇H₁,B₇H₂,ICOS mRNA were detected in both cancer cells and tumor infiltrating lymphocytes (TIL). The mRNA expression level of these molecules in tumor cells was higher than that in TIL (0.76 ± 0.54-1.62 ± 0.82 vs 0.38 ± 0.19-0.65 ± 0.33, P<0.001). There was no relationship between expression level of tested B₇ family molecules and patients’ sex, age, differentiation status of cancer and regional lymph node metastasis.

CONCLUSION: Th2 cytokine predominant in tumor microenvironment might be related to the expression of B₇H₁,B₇H₂ co-signal molecules in tumor cells and TIL.

Keywords: Colorectal cancer; B_7-1, B7H1, B7H2 and ICOS; Tumor immunity; Immune evasion