B7 molecule mRNA expression in colorectal carcinoma

doi:10.3748/wjg.v11.i36.5655

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 11, Issue 36

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (1999)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-1) series, Tables (1-3) series.

Item

Count

PDF

207

HTML

1537

Figures (1-1)

124

Tables (1-3)

131

Sum=1999

Sep 28, 2005 (publication date) through May 4, 2024

Times Cited of This Article

Times Cited (11)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Sep 28, 2005; 11(36): 5655-5658
Published online Sep 28, 2005. doi: 10.3748/wjg.v11.i36.5655

B₇ molecule mRNA expression in colorectal carcinoma

Ju-Xiang Xiao, Pei-Song Bai, Bao-Chang Lai, Li Li, Juan Zhu, Yi-Li Wang

Ju-Xiang Xiao, Pei-Song Bai, Li Li, Juan Zhu, Department of Oncology, First Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China

Bao-Chang Lai, Yi-Li Wang, Institute for Cancer research, School of Life Science and Technology of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China

Author contributions: All authors contributed equally to the work.

Supported by the National Natural Science Foundation of China, No. 30370549

Correspondence to: Dr. Ju-Xiang Xiao, Department of Oncology, First Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China. xiao_juxiang@yahoo.com

Telephone: +86-29-85324068 Fax: +86-29-85237369

Received: May 13, 2005
Revised: June 2, 2005
Accepted: June 6, 2005
Published online: September 28, 2005

Abstract

AIM: To observe the status of tumor-associated B₇ molecule mRNA expression in human colorectal cancer tissue by in situ hybridization.

METHODS: The mRNA expression patterns of cancer-associated B_7-1,B₇H₁,B₇H₂,ICOS in 22 specimens of human colorectal cancer tissue were monitored by in situ hybridization (ISH) with digoxin-labeled oligonucleotide probes.

RESULTS: B_7-1,B₇H₁,B₇H₂,ICOS mRNA were detected in both cancer cells and tumor infiltrating lymphocytes (TIL). The mRNA expression level of these molecules in tumor cells was higher than that in TIL (0.76 ± 0.54-1.62 ± 0.82 vs 0.38 ± 0.19-0.65 ± 0.33, P<0.001). There was no relationship between expression level of tested B₇ family molecules and patients’ sex, age, differentiation status of cancer and regional lymph node metastasis.

CONCLUSION: Th2 cytokine predominant in tumor microenvironment might be related to the expression of B₇H₁,B₇H₂ co-signal molecules in tumor cells and TIL.

Keywords: Colorectal cancer, B_7-1, B7H1, B7H2 and ICOS, Tumor immunity, Immune evasion