Brief Reports
Copyright ©2005 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2005; 11(35): 5565-5567
Published online Sep 21, 2005. doi: 10.3748/wjg.v11.i35.5565
Detection of HBsAg, HBcAg, and HBV DNA in ovarian tissues from patients with HBV infection
Li-Zhang Chen, Xue-Gong Fan, Jian-Ming Gao
Li-Zhang Chen, Jian-Ming Gao, School of Public Health, Central South University, Changsha 410078, Hunan Province, China
Xue-Gong Fan, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410078, Hunan Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Li-Zhang Chen, School of Public Health, Central South University, Changsha 410078, Hunan Province, China. chenliz@mail.csu.edu.cn
Telephone: +86-731-8836971 Fax: +86-731-8836266
Received: September 9, 2004
Revised: January 23, 2005
Accepted: January 26, 2005
Published online: September 21, 2005
Abstract

AIM: To investigate the presence of HBsAg, HBcAg, and HBV DNA in ovarian tissues from patients with HBV infection.

METHODS: HBsAg and HBcAg were examined in ovarian biopsy tissues from 26 patients with HBV infection by immunocytochemistry, and HBV DNA was detected in ovarian tissues by PCR.

RESULTS: HBsAg and HBcAg were present with the same positive rate of 34.6% (9/26). The total positive rate was 46.2% (12/26). HBsAg and HBcAg were positive in 6 (23.1%) of the 26 patients. Brown positive particles were diffusely distributed in ovarian cells. The positive rate of HBV DNA was 58.3% (7/12).

CONCLUSION: HBsAg, HBcAg, and HBV DNA can be detected in ovarian tissues from patients with HBV infection. The presence of HBsAg and HBcAg in ovarian tissues does not correlate with the HBV markers in serum.

Keywords: Ovarian tissue; HBsAg; HBcAg; HBV DNA