Brief Reports
Copyright ©2005 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2005; 11(35): 5545-5548
Published online Sep 21, 2005. doi: 10.3748/wjg.v11.i35.5545
Evaluation of urine ELISA test for detecting Helicobacter pylori infection in Taiwan: A prospective study
Fu-Chen Kuo, Sheng-Wen Wang, I-Chen Wu, Fang-Jung Yu, Yuan-Chieh Yang, Jeng-Yih Wu, Wen-Ming Wang, Deng-Chyang Wu
Fu-Chen Kuo, Department of Gynecology and Obstetrics, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan, China
Sheng-Wen Wang, I-Chen Wu, Fang-Jung Yu, Jeng-Yih Wu, Wen-Ming Wang, Deng-Chyang Wu, Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan, China
Yuan-Chieh Yang, Department of Clinical Pathology, Kaohsiung Medical University Hospital, Taiwan, China
Author contributions: All authors contributed equally to the work.
Supported by the grants from the National Science Council of the Taiwan, No. NSC91-2315-B-037-003
Correspondence to: Dr. Deng-Chyang Wu, Chief of Gastroenterology, Kaohsiung Medical University Hospital, 100 Zih-You 1st Road, Kaohsiung City, 807 Taiwan, China. dechwu@yahoo.com
Telephone: +886-7-3121101-7451 Fax: +886-7-3135612
Received: December 14, 2004
Revised: January 2, 2005
Accepted: January 5, 2005
Published online: September 21, 2005
Abstract

AIM: To evaluate the diagnostic accuracy and clinical utility of a new ELISA (URINELISA) test for detecting Helicobacter pylori (H pylori) antibody in the urine of Taiwanese population.

METHODS: In this prospective study, 317 consecutive dyspeptic patients (171 men, 146 women; mean age, 51.0 years) were included. They underwent gastroendoscopy for evaluation. Invasive tests, including culture, histology, and rapid urease test (RUT), and non-invasive 13C-urea breath test were preformed. At the same time, urine specimens were collected for URINELISA. The status of H pylori infection was considered as positive when either culture was positive, or when two of the other, RUT, histology or 13C-UBT, were positive.

RESULTS: The sensitivity, specificity, positive predictive value, and negative predictive value of URINELISA are 91.7% (211/230), 90.8% (79/87), 96.3% (211/219), and 80.6% (79/98) respectively.

CONCLUSION: This URINELISA test is reliable, inexpensive and easy-to-use. The high diagnostic accuracy warrants the use of URINELISA as a first-line screening tool for diagnosis of H pylori infection in untreated patients.

Keywords: H pylori, URINELISA