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Copyright ©The Author(s) 2005. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2005; 11(34): 5377-5380
Published online Sep 14, 2005. doi: 10.3748/wjg.v11.i34.5377
Relationship between entero-hepatic bile acid circulation and interdigestive migrating myoelectrical activity in rats
Ping Fang, Lei Dong, Wei-Jin Zhang, Jin-Yan Luo
Ping Fang, Lei Dong, Jin-Yan Luo, Department of Internal Medicine, Second Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Wei-Jin Zhang, Division of Cardiovascular Physiology and Pharmacology, Medical School of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Author contributions: All authors contributed equally to the work.
Supported by National Natural Science Foundation of China, No. 30170414
Correspondence to: Professor Lei Dong, Department of Internal Medicine, Second Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China. pingf7613@sina.com
Telephone: +86-29-87679368
Received: October 9, 2004
Revised: December 14, 2004
Accepted: December 19, 2004
Published online: September 14, 2005
Abstract

AIM: To investigate the effects of entero-hepatic bile acid circulation on the inter-digestive migrating myoelectrical complex (MMC) in rats.

METHODS: Thirty-two rats were divided into four groups. Three pairs of bipolar silver electrodes were chronically implanted in the antrum, duodenum and jejunum. Three groups of them were ligated around the upper part of common bile duct (CBD). The experiments were performed in conscious and fasting state. The gastrointestinal myoelectrical activity was recorded. Ursodeoxycholic acid (UDCA) and saline were then perfused into stomachs of two groups with CBD obstruction and the effects of them on the MMC were observed.

RESULTS: A typical pattern of MMC was observed in normal fasting rats. MMC of antral and duodenal origin disappeared temporarily in earlier stage of CBD obstruction. While MMC of jejunum origin appeared. increased MMC cycle duration was seen after 4 d in rats with CBD obstruction. The MMC after CBD obstruction was characterized by an increased duration of phase II-like activity and decreased duration of phase I & III activity. Perfusion into stomachs with UDCA resulted in a shorter MMC cycle duration and a longer duration of phase III of duodenal origin compared to the normal group.

CONCLUSION: Entero-hepatic bile acid circulation initiates inter-digestive MMC of duodenal origin.

Keywords: Migrating myoelectrical complex; Entero-hepatic Bile acid circulation; Ursodeoxycholic acid; Common bile duct obstruction