Gastroprotection induced by capsaicin in healthy human subjects

doi:10.3748/wjg.v11.i33.5180

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Research

World J Gastroenterol. Sep 7, 2005; 11(33): 5180-5184
Published online Sep 7, 2005. doi: 10.3748/wjg.v11.i33.5180

Gastroprotection induced by capsaicin in healthy human subjects

Gyula Mózsik, János Szolcsányi, István Rácz

Gyula Mózsik, First Department of Medicine, Medical and Health Center, University of Pécs, Hungary

János Szolcsányi, Department of Pharmacology and Pharmacotherapy, Medical and Health Center, University of Pécs, Hungary

István Rácz, First Department of Medicine, County Hospital of Gyõr, Hungary

Author contributions: All authors contributed equally to the work.

Correspondence to: Professor Gyula Mózsik, MD, First Department of Medicine, Medical and Health Center, University of Pécs, Hungary. gyula.mozsik@aok.pte.hu

Telephone: +36-72-536-494 Fax: +36-72-536-495

Received: October 14, 2004
Revised: December 21, 2004
Accepted: December 23, 2004
Published online: September 7, 2005

Abstract

AIM: To evaluate the gastro-protective effect of capsaicin against the ethanol- and indomethacin (IND)-induced gastric mucosal damage in healthy human subjects.

METHODS: The effects of small doses (1-8 μg/mL, 100 mL) of capsaicin on the gastric acid secretion basal acid output (BAO) and its electrolyte concentration, gastric transmucosal potential difference (GTPD), ethanol- (5 mL 300 mL/L i.g.) and IND- (3×25 mg/d) induced gastric mucosal damage were tested in a randomized, prospective study of 84 healthy human subjects. The possible role of desensitization of capsaicin-sensitive afferents was tested by repeated exposures and during a prolonged treatment.

RESULTS: Intragastric application of capsaicin decreased the BAO and enhanced “non-parietal” component (GTPD) in a dose-dependent manner. The decrease of GTPD evoked by ethanol was inhibited by the capsaicin application, which was reproducible. Gastric microbleeding induced by IND was inhibited by co-administration with capsaicin, but was not influenced by two weeks pretreatment with a daily capsaicin dose of 3×400 μg i.g.

CONCLUSION: Capsaicin in low concentration range protects against gastric injuries induced by ethanol or IND, which is attributed to stimulation of the sensory nerve endings.

Keywords: Capsaicin; Ethanol; Indomethacin; Gastric transmucosal potential difference; Gastric microbleeding; Gastroprotection; Healthy human subjects