Liu CY, Liao HF, Wang TE, Lin SC, Shih SC, Chang WH, Yang YC, Lin CC, Chen YJ. Etoposide sensitizes CT26 colorectal adenocarcinoma to radiation therapy in BALB/c mice. World J Gastroenterol 2005; 11(31): 4895-4898 [PMID: 16097067 DOI: 10.3748/wjg.v11.i31.4895]
Corresponding Author of This Article
Yu-Jen Chen, Department of Radiation Oncology, Mackay Memorial Hospital, No. 92, Section 2, Chung San North Road, Taipei 104, Taiwan, China. chenmdphd@yahoo.com
Article-Type of This Article
Brief Reports
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Chia-Yuan Liu, Tsang-En Wang, Shee-Chan Lin, Shou-Chuan Shih, Wen-Hsuing Chang, Ching-Chung Lin, Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan, China
Chia-Yuan Liu, Hui-Fen Liao, Yuh-Cheng Yang, Yu-Jen Chen, Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan, China
Hui-Fen Liao, Department of Molecular Biology and Biochemistry, National Chiayi University, Chiayi, 300 Taiwan, China
Shou-Chuan Shih, Yuh-Cheng Yang, Mackay Medicine, Nursing and Management College, Taipei, Taiwan, China
Yu-Jen Chen, Department of Radiation Oncology, Mackay Memorial Hospital, Taipei, Taiwan, China
Author contributions: All authors contributed equally to the work.
Supported by the Grant, No. MMH 9352 from Mackay Memorial Hospital, Taipei, Taiwan, China
Correspondence to: Yu-Jen Chen, Department of Radiation Oncology, Mackay Memorial Hospital, No. 92, Section 2, Chung San North Road, Taipei 104, Taiwan, China. chenmdphd@yahoo.com
Telephone: +886-2-28094661 Fax: +886-2-28096180
Received: December 13, 2004 Revised: January 23, 2005 Accepted: January 26, 2005 Published online: August 21, 2005
Abstract
AIM: To investigate the combined effect of etoposide and radiation on CT26 colorectal adenocarcinoma implanted into BALB/c mice.
METHODS: We evaluated the radiosensitizing effect of etoposide on CT26 colorectal adenocarcinoma in a syngeneic animal model. BALB/c mice were subcutaneously implanted with CT26 cells and divided into four groups: control (intra-peritoneal saline2) group, etoposide (5 mg/kg intra-peritoneally2) group, radiation therapy (RT 5 Gy2 fractions) group, and combination therapy with etoposide (5 mg/kg intra-peritoneally 1 h before radiation) group.
RESULTS: Tumor growth was significantly inhibited by RT and combination therapy. The effect of combination therapy was better than that of RT. No significant changes were noted in body weight, plasma alanine aminotransferase, or creatinine in any group. The leukocyte count significantly but transiently decreased in the RT and combination therapy groups, but not in the etoposide and control groups. There was no skin change or hair loss in the RT and combination therapy groups.
CONCLUSION: Etoposide can sensitize CT26 colorectal adenocarcinoma in BALB/c mice to RT without significant toxicity.
