Overexpression of S100A4 is closely associated with progression of colorectal cancer

doi:10.3748/wjg.v11.i31.4852

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 21, 2005; 11(31): 4852-4856
Published online Aug 21, 2005. doi: 10.3748/wjg.v11.i31.4852

Overexpression of S100A4 is closely associated with progression of colorectal cancer

Yong-Gu Cho, Chang-Jae Kim, Suk-Woo Nam, Shin-Hee Yoon, Sug-Hyung Lee, Nam-Jin Yoo, Jung-Young Lee, Won-Sang Park

Yong-Gu Cho, Chang-Jae Kim, Suk-Woo Nam, Sug-Hyung Lee, Nam-Jin Yoo, Jung-Young Lee, Won-Sang Park, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, South Korea

Shin-Hee Yoon, Department of Physiology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, South Korea

Author contributions: All authors contributed equally to the work.

Supported by the Korea Science and Engineering Foundation, No. R13-2002-005-01004-0

Correspondence to: Dr. Won-Sang Park, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, South Korea. wonsang@catholic.ac.kr

Telephone: +82-2-590-1192 Fax: +82-2-537-6586

Received: January 11, 2005
Revised: January 23, 2005
Accepted: January 26, 2005
Published online: August 21, 2005

Abstract

AIM: To investigate whether S100A4 played an important role in the development or progression of colorectal cancer.

METHODS: A total of 124 colorectal adenocarcinoma tissue specimens were analyzed by immunohistochemistry for the expression of S100A4 protein and subsequently investigated for the gene mutations in the coding region of S100A4 gene. The specimens were collected over a 3-year period in the laboratories at our large teaching hospital in Seoul, Republic of Korea.

RESULTS: Normal colonic epithelium either failed to express or showed focal weak expression of S100A4. Moderate to strong cytoplasmic expression of S100A4 was seen in 69 (55.6%) of the 124 colorectal carcinoma tissue specimens. S100A4 expression was detected in 43 (69.4%) of 62 specimens with lymph node metastasis. Statistically, overexpression of S100A4 was significantly associated with Dukes stage and lymph node metastasis. Nuclear staining was also observed in 24 (19.4%) of 124 samples and closely associated with Dukes stage. However, there was no significant correlation between overexpression of S100A4 and other investigated clinico-pathologic parameters, including tumor localization, tumor size, and survival period. In mutational analysis, no gene mutation was found in the analyzed genomic area of colorectal cancer.

CONCLUSION: Overexpression of S100A4 may be closely related with the aggressiveness of colorectal carcinoma.

Keywords: S100A4; Mutation; Immunohistochemistry; Colorectal cancer; Tumor stage