Expression of a novel apoptosis inhibitor-survivin in colorectal carcinoma

doi:10.3748/wjg.v11.i30.4689

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Aug 14, 2005; 11(30): 4689-4692
Published online Aug 14, 2005. doi: 10.3748/wjg.v11.i30.4689

Expression of a novel apoptosis inhibitor-survivin in colorectal carcinoma

Hai-Yan Tan, Jun Liu, Shan-Min Wu, He-Sheng Luo

Hai-Yan Tan, Shan-Min Wu, Department of General surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China

Jun Liu, He-Sheng Luo, Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Hai-Yan Tan, Department of General Surgery, Renmin Hospital of Wuhan University, Jiefang Road No. 238, Wuhan 4300 60, Hubei Province, China. liu9861jun@yahoo.com.cn

Telephone: +86-27-88054316

Received: August 30, 2004
Revised: November 1, 2004
Accepted: November 4, 2004
Published online: August 14, 2005

Abstract

AIM: To investigate the role of survivin expression in the pathogenesis of colorectal carcinoma.

METHODS: Immunohistochemistry S-P method and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) were used to detect the expression of survivin and apoptotic cell in situ in colorectal cancerous tissues, para-cancerous tissues and normal tissues of 48 cases of colorectal carcinoma.

RESULTS: The survivin positive unit (PU) was higher in cancerous tissues (38.76 ± 5.14) than in para-cancerous (25.17 ± 7.26) or normal tissues (0.57 ± 0.03) (P < 0.05). The apoptosis index (AI) of para-cancerous tissues was (7.51 ± 2.63%) higher than cancerous tissues (4.65 ± 1.76%). The expression of survivin was associated with pathological grade, lymph node metastasis and Dukes stage of colorectal carcinoma.

CONCLUSION: Survivin expression may play an important role in carcinogenesis of colorectal carcinoma and may be associated with malignant biological behaviors of colorectal carcinoma.

Keywords: Survivin; Colorectal carcinoma; Cell apoptosis