Basic Research
Copyright ©The Author(s) 2005. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2005; 11(29): 4536-4540
Published online Aug 7, 2005. doi: 10.3748/wjg.v11.i29.4536
Characteristics of benign lymphoadenosis of oral mucosa
Shu-Xia Li, Shi-Feng Yu, Kai-Hua Sun
Shu-Xia Li, Shi-Feng Yu, Kai-Hua Sun, Department of Oral Pathology, School of Stomatology, Peking University, Beijing 100081, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Shu-Xia Li, Department of Oral Pathology, School of Stomatology, Peking University, Beijing 100081, China. lishuxia@sina.com
Telephone: +86-10-62179977-2201
Received: June 8, 2004
Revised: August 1, 2004
Accepted: August 5, 2004
Published online: August 7, 2005
Abstract

AIM: To investigate the pathological characteristics and carcinogenesis mechanism of benign lymphoadenosis of oral mucosa (BLOM).

METHODS: The expressions of Ki-67, CD34 and apoptosis were evaluated by immunohistochemical SP staining in 64 paraffin-embedded tissue samples. Of them, 9 were from BLOM with dysplasia, 15 from BLOM without dysplasia, 15 from oral squamous cell carcinoma (OSCC), 15 from oral precancerosis, and 10 from normal tissues. Cell proliferation, apoptosis and angiogenesis of tissue samples were also analyzed.

RESULTS: The expression of Ki-67 in BLOM with dysplasia, oral precancerosis and OSCC was significantly higher than in BLOM without dysplasia and normal mucosa. The microvascular density (MVD) in BLOM with and without dysplasia, oral precancerosis, and OSCC was significantly higher than in normal mucosa. Apoptosis in BLOM and oral precancerosis was significantly higher than in OSCC and normal mucosa.

CONCLUSION: Benign lymphoadenosis of oral mucosa has potentialities of cancerization.

Keywords: Benign lymphoadenosis of oral mucosa; Ki-67; Microvascular density; Apoptosis