Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh&rsquo;s esophageal squamous cell cancer in Xinjiang, China

doi:10.3748/wjg.v11.i24.3651

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Jun 28, 2005 (publication date) through Nov 30, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Esophageal Cancer

World J Gastroenterol. Jun 28, 2005; 11(24): 3651-3654
Published online Jun 28, 2005. doi: 10.3748/wjg.v11.i24.3651

Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh’s esophageal squamous cell cancer in Xinjiang, China

Xiao-Mei Lu, Yue-Ming Zhang, Ren-Yong Lin, Arzi Gul, Xing Wang, Ya-Lou Zhang, Yan Zhang, Yan Wang, Hao Wen

Xiao-Mei Lu, Ren-Yong Lin, Arzi Gul, Xing Wang, Ya-Lou Zhang, Yan Zhang, Yan Wang, Hao Wen, Medical Research Center, 1^st Teaching Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China

Yue-Ming Zhang, Public Health College, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China

Author contributions: All authors contributed equally to the work.

Supported by the Xinjiang Key Lab Fund, XJDX0202-2003-05

Correspondence to: Hao Wen, PhD, Medical Research Center, 1^st Teaching Hospital, Xinjiang Medical University, No. 1 Liyushan Road, Urumqi 830054, Xinjiang Uygur Autonomous Region, China. wenhao2002@hotmail.com

Telephone: +86-991-4362844 Fax: +86-991-4324139

Received: May 25, 2004
Revised: May 26, 2004
Accepted: June 18, 2004
Published online: June 28, 2005

Abstract

AIM: To analyze the relationship between genetic polym-orphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh’s esophageal squamous cell cancer in China.

METHODS: The genotypes of cytochromes P450 (CYP) 2E1 and glutathione S-transferase (GST) M1 were investigated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) following PCR in 104 Kazakh’s patients with esophageal cancer (EC) and 104 non-cancer controls.

RESULTS: The frequency of CYP2E1 c1/c1 genotype was significantly higher in patients with cancer (77.9%) than in control subjects (24.0%) (P<0.05; OR, 11.13; 95%CI, 5.84-21.22). The difference of GSTM1 null was significantly more frequent in the cancer (34.6%) vs the control group (3.8%) (P<0.05; OR, 13.24; 95%CI, 4.50-38.89). On the other hand, the combination of GSTM1 presence and CYP2E1 c1/c1 genotypes increased the risk for cancer (P<0.05; OR, 13.42; 95%CI, 6.29-28.3).

CONCLUSION: The CYP2E1 c1/c1, GSTM1 deletion genotypes are genetically susceptible biomarkers for ESCC in Kazakh population. Individuals with allele c1 of RsaI polymorphic locus for CYP2E1 may increase the risk of ESCC. Moreover, CYP2E1 wild type (c1/c1) increased the susceptibility to ESCC risk in Kazakh individuals with GSTM1 presence genotype.

Keywords: Polymorphisms; CYP2E1; GSTM1; Kazakh’s esophageal squamous cell cancer