Helicobacter Pylori
Copyright ©2005 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2005; 11(23): 3523-3527
Published online Jun 21, 2005. doi: 10.3748/wjg.v11.i23.3523
Distribution of Helicobacter pylori in north China
Yue-Hua Gong, Ying Wang, Yuan Yuan
Yue-Hua Gong, Ying Wang, Yuan Yuan, Cancer Institute of the First Affiliated Hospital of China Medical University Shenyang 110001, Liaoning Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Professor Yuan Yuan, Cancer institute of the First Affiliated Hospital of China Medical University, 155 Northern Nanjing Street, Heping District, Shenyang 110001, Liaoning Province, China. yyuan@mail.cmu.edu.cn
Telephone: +86-24-23256666-6153 Fax: +86-24-22703576
Received: July 2, 2004
Revised: July 3, 2004
Accepted: August 30, 2004
Published online: June 21, 2005
Abstract

AIM: To compare the distribution of virulence-associated genotypes of Helicobacter pylori (H pylori) in two areas of north China with different gastric cancer risk and furthermore probe into the pathogenicity of the bacterium.

METHODS: Gastric biopsies were taken from 355 subjects from Zhuanghe, a high risk area of gastric cancer, and 136 subjects from Shenyang, a low risk area of gastric cancer. A total of 149 H pylori strains isolated from these patients were studied by PCR for differences in the genotypes of cagA, vacA, and iceA.

RESULTS: In patients with high risk for gastric cancer, higher frequencies of vacA s1 or s1m1b genotypes were found as compared to those from the low risk area.

CONCLUSION: There is significantly different distribution of H pylori genotypes between Zhuanghe and Shenyang areas in north China.

Keywords: Helicobacter pylori; Gastric disease; cagA; vacA; iceA; Virulence genotype; High-risk area