Quality of gastric ulcer healing evaluated by endoscopic ultrasonography

doi:10.3748/wjg.v11.i22.3461

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jun 14, 2005; 11(22): 3461-3464
Published online Jun 14, 2005. doi: 10.3748/wjg.v11.i22.3461

Quality of gastric ulcer healing evaluated by endoscopic ultrasonography

Jian-Min Si, Qian Cao, Jia-Guo Wu

Jian-Min Si, Qian Cao, Jia-Guo Wu, Gastroenterology Laboratory, Institute of Clinical Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Professor Jian-Min Si, Gastroenterology Laboratory, Institute of Clinical Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang Province, China. sijm@163.net

Telephone: +86-571-87217002 Fax: +86-571-87217044

Received: August 26, 2004
Revised: August 28, 2004
Accepted: November 4, 2004
Published online: June 14, 2005

Abstract

AIM: To evaluate the quality of gastric ulcer healing after different antiulcer treatment by endoscopic ultrasonography (EUS).

METHODS: The patients were divided into three groups, and received lansoprazole, amoxicillin and clarithromycin for 1 wk. Then group A took lansoprazole combined with tepreton for 5 wk, group B took lansoprazole and group C took tepreton for 5 wk. Endoscopy and EUS were performed before and 6 wk after medication.

RESULTS: There was no significant difference in cumulative healing rate to S stage between the groups (89%, 82% vs 83%, P>0.05). The rate of white scar formation was significantly higher in group A than in groups B and C (67%, 36%, 50%, P<0.05). The average contraction rates of the width of ulcer crater, length of disrupted muscularis propria layer and hypoechoic area were higher in group A than in groups B and C (0.792±0.090, 0.660±0.105 vs 0.668±0.143, P<0.05). The hypoechoic area disappeared in four cases of group A, one of group B and two of group C. The percentage of hypoechoic area disappearance was higher in group A than in the other two groups (44%, 9% vs 17%, P<0.05). Gastric ulcer healing was better in group A.

CONCLUSION: The combined administration of proton-pump inhibitors and mucosal protective agent can improve gastric ulcer healing.

Keywords: Quality of ulcer healing; Endoscopic ultrasono-graphy; Gastric ulcer