Tissue distribution and excretion of 125I-lidamycin in mice and rats

doi:10.3748/wjg.v11.i21.3281

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Jun 7, 2005 (publication date) through Aug 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2005; 11(21): 3281-3284
Published online Jun 7, 2005. doi: 10.3748/wjg.v11.i21.3281

Tissue distribution and excretion of ¹²⁵I-lidamycin in mice and rats

You-Ping Liu, Quan-Sheng Li, Yu-Rong Huang, Chang-Xiao Liu

You-Ping Liu, National Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, 308 An-Shan West Road, Tianjin 300193, China

You-Ping Liu, Laboratory of Drug Metabolism Pharmacokinetics, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, Liaoning Province, China

Chang-Xiao Liu, Quan-Sheng Li, Yu-Rong Huang, National Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Academician Chang-Xiao Liu, Tianjin Institute of Pharmaceutical Research, 308 An-Shan West Road, Tianjin 300193, China. liuchangxiao@163.com

Telephone: +86-22-2300-6863 Fax: +86-22-2300-6860

Received: March 9, 2004
Revised: March 10, 2004
Accepted: April 13, 2004
Published online: June 7, 2005

Abstract

AIM: To investigate the tissue distribution, urinary and fecal excretions of ¹²⁵I-lidamycin (¹²⁵I-C-1027) in mice and its biliary excretion in rats.

METHODS: The total radioactivity assay (RA method) and the radioactivity assay after precipitation with 200 mL/L trichloroacetic acid (TCA-RA method) were used to dete-rmine the tissue distribution, and the urinary and fecal excretions of ¹²⁵I-C-1027 in mice and its biliary excretion in rats.

RESULTS: Tissue concentrations reached the peak at the fifth minute after administration of ¹²⁵I-C-1027 to mice. The highest concentration was in kidney, and the lowest in brain at all test-time points. The organs of the concentr-ations of ¹²⁵I-C-1027 from high to low were kidney, lung, liver, stomach, spleen, uterus, ovary, intestine, muscle, heart, testis, fat, and brain in mice. The accumulative excretion amounts of 0-24 h, and 0-96 h after administration of ¹²⁵I-C-1027 were 68.36 and 71.64% in urine, and 2.60 and 3.21% in feces of mice, respectively, and the accumulative excretion amount of 0-24 h was 3.57% in bile in rats.

CONCLUSION: Our results reflect the characteristics of the tissue distribution, urinary and fecal excretions of ¹²⁵I-C-1027 in mice and the biliary excretion of ¹²⁵I-C-1027 and its metabolites in rats, and indicate that ¹²⁵I-C-1027 and its metabolites are mainly distributed in kidney, and excreted in urine.

Keywords: Distribution; Excretion; Lidamycin; C-1027; RA method; TCA-RA method