Analyses of prognostic indices of chronic liver failure caused by hepatitis virus

doi:10.3748/wjg.v11.i18.2841

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2005; 11(18): 2841-2843
Published online May 14, 2005. doi: 10.3748/wjg.v11.i18.2841

Analyses of prognostic indices of chronic liver failure caused by hepatitis virus

Xiao-Mao Li, Lin Ma, Yue-Bo Yang, Zhong-Jie Shi, Shui-Sheng Zhou

Xiao-Mao Li, Lin Ma, Yue-Bo Yang, Zhong-Jie Shi, Shui-Sheng Zhou, Department of Obstetrics and Gynecology, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Professor Xiao-Mao Li, Department of Obstetrics and Gynecology, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China. tigerlee777@163.net

Telephone: +86-20-85515609 Fax: +86-20-87565575

Received: October 26, 2004
Revised: October 28, 2004
Accepted: December 21, 2004
Published online: May 14, 2005

Abstract

AIM: To analyze the related indices about the prognoses of chronic liver failure caused by hepatitis virus.

METHODS: Retrospectively reviewed 320 cases of chronic liver failure caused by hepatitis viruses. An improved group and an ineffective group (IG) were made to compare and analyze their clinical manifestations, laboratory examination indices and complications. Logistic regression was also carried out.

RESULTS: There were significant differences (P<0.05) between the improved group and the IG upon such indices as age, bilirubin, prothrombin time, albumin, alpha fetoprotein, the size of liver and complications (P<0.05). The regression formula was as follows: P = 1/(1+e^-y) (y = 1.7262-0.0948X₁+2.9846X₂+0.6992X₃+1.6019X₄+ 2.0398X₅). (Note: X₁-Prothrombin activity; X₂-digestive tract hemorrhage; X₃-hepatic encephalopathy; X₄-hepatorenal syndrome; X₅-pulmonary infection.).

CONCLUSION: Laboratory examination such as bilirubin, prothrombin time and alpha fetoprotein can be regarded as indices of the prognoses of chronic liver failure caused by hepatitis. Moreover, the regression equation can evaluate prognoses more comprehensively and direct our treatments.

Keywords: Chronic liver failure; Hepatitis; Prognostic indices; Laboratory indices; Complications; Regression equation