Case Report
Copyright ©2005 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2005; 11(13): 2035-2038
Published online Apr 7, 2005. doi: 10.3748/wjg.v11.i13.2035
Transhepatic fibrinolysis of mesenteric and portal vein thrombosis in a patient with ulcerative colitis: A case report
Alfredo Guglielmi, Francesca Fior, Orsolya Halmos, Gian Franco Veraldi, Lorenzo Rossaro, Andrea Ruzzenente, Claudio Cordiano
Alfredo Guglielmi, Francesca Fior, Orsolya Halmos, Gian Franco Veraldi, Andrea Ruzzenente, Claudio Cordiano, First Department of General Surgery, University of Verona, Borgo Trento Hospital, P.le Stefani 1, 37126 Verona, Italy
Lorenzo Rossaro, Department of Internal Medicine, University of California Davis Medical Centre, Sacramento, California, USA
Author contributions: All authors contributed equally to the work.
Correspondence to: Professor Alfredo Guglielmi, First Department of General Surgery, University of verona, Borgo Trento Hospital, P.le Stefani 1, 37126 Verona, Italy. alfredo.guglielmi@univr.it
Telephone: +39-45-8073123 Fax: +39-45-8072484
Received: March 15, 2004
Revised: March 16, 2004
Accepted: June 25, 2004
Published online: April 7, 2005
Abstract

AIM: To present a case of acute mesenteric and portal vein thrombosis treated with thrombolytic therapy in a patient with ulcerative colitis in acute phase and to review the literature on thrombolytic therapy of mesenteric-portal system. Treatment of acute portal vein thrombosis has ranged from conservative treatment with thrombolysis and anticoagulation therapy to surgical treatment with thrombectomy and/or intestinal resection.

METHODS: We treated our patient with intraportal infusion of plasminogen activator and then heparin through a percutaneous transhepatic catheter.

RESULTS: Thrombus resolved despite premature interruption of the thrombolytic treatment for neurological complications, which subsequently resolved.

CONCLUSION: Conservative management with plasminogen activator, could be considered as a good treatment for patients with acute porto-mesenteric thrombosis.

Keywords: Acute mesenteric; Portal vein thrombosis