Serum IL-6, TNF&alpha; and CRP levels in Greek colorectal cancer patients: Prognostic implications

doi:10.3748/wjg.v11.i11.1639

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Mar 21, 2005 (publication date) through Nov 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2005; 11(11): 1639-1643
Published online Mar 21, 2005. doi: 10.3748/wjg.v11.i11.1639

Serum IL-6, TNFα and CRP levels in Greek colorectal cancer patients: Prognostic implications

Nikolaos I. Nikiteas, Nikolaos Tzanakis, Maria Gazouli, George Rallis, Kessaris Daniilidis, George Theodoropoulos, Alkiviadis Kostakis, George Peros

Nikolaos I. Nikiteas, Alkiviadis Kostakis, 2^nd Propedeutic Department of Surgery, School of Medicine, University of Athens, 11527 Athens, Greece

Nikolaos Tzanakis, George Rallis, Kessaris Daniilidis, George Peros, Department of Surgery, School of Medicine, University of Athens, 11527 Athens, Greece

Maria Gazouli, Department of Biology, School of Medicine, University of Athens, 11527 Athens, Greece

George Theodoropoulos, 1^st Propedeutic Surgical Department, Hippocration University Hospital, 11524 Athens, Greece

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Nikolaos I. Nikiteas, 2^nd Propedeutic Department of Surgery, Laikon Hospital, Agiou Thoma 15-17, Athens 11527, Greece. nnkit@med.uoa.gr

Telephone: +30-2107772181 Fax: +30-2107791456

Received: August 13, 2004
Revised: September 1, 2004
Accepted: September 30, 2004
Published online: March 21, 2005

Abstract

AIM: The significance of preoperative serum IL-6, TNFα and CRP levels in the progression of colorectal cancer (CRC) has not been fully elucidated. Our intention was to investigate their role and identify their prognostic significance.

METHODS: The IL-6, TNFα and CRP levels were measured in 74 CRC patients and the relationships between their elevations and both the clinicopathological factors and prognosis of patients were investigated. Serum concentrations of human IL-6 and TNFα were determined by enzyme-linked immunosorbent assay (ELISA). CRP was measured by an immunoturbinometric method.

RESULTS: Median IL-6, TNFα and CRP levels were significantly higher in CRC patients than in normal controls. High levels of serum IL-6, TNFα and CRP were correlated with larger tumor size. Furthermore, high IL-6 and high CRP levels were associated with reduced overall survival.

CONCLUSION: Serum IL-6, TNFα and CRP levels definitely increase in CRC patients. Pre-operative serum elevation of IL-6 and CRP was thus found to be predictor of the prognosis of CRC patients. The clinical value of TNFα in CRC needs to be further investigated.

Keywords: IL-6; TNFα; CRP; Colorectal cancer