Gastric Cancer
Copyright ©2005 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 7, 2005; 11(1): 56-60
Published online Jan 7, 2005. doi: 10.3748/wjg.v11.i1.56
E-cadherin gene C-160A promoter polymorphism and risk of non-cardia gastric cancer in a Chinese population
Yan Lu, Yao-Chu Xu, Jing Shen, Rong-Bin Yu, Ju-Yin Niu, Jian-Tao Guo, Xu Hu, Hong-Bing Shen
Yan Lu, Yao-Chu Xu, Jing Shen, Rong-Bin Yu, Ju-Yin Niu, Hong-Bing Shen, Department of Epidemiology and Biostatistics, Nanjing Medical University School of Public Health, Nanjing 210029, Jiangsu Province, China
Jian-Tao Guo, Jintan Center for Disease Control and Prevention, Jintan City 213200, Jiangsu Province, China
Xu Hu, Huaian Center for Disease Control and Prevention, Huaian 223200, Jiangsu Province, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No. 30271148 and 30170827
Correspondence to: Dr. Hong-Bing Shen, Department of Epidemiology and Biostatistics, Nanjing Medical University School of Public Health, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. hbshen@njmu.edu.cn
Telephone: +86-25-86862935 Fax: +86-25-86527613
Received: February 21, 2004
Revised: February 23, 2004
Accepted: March 18, 2004
Published online: January 7, 2005
Abstract

AIM: To test the hypothesis that E-cadherin gene (CDH1) C-160A promoter variant genotype is associated with an increased risk for developing gastric cancer.

METHODS: In this population-based case-control study of gastric cancer in Jiangsu Province, China, we performed polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to genotype the C-160A polymorphism of CDH1 promoter in 206 non-cardia gastric cancer patients and 261 age- and sex-matched but unrelated cancer-free controls.

RESULTS: The frequencies of genotypes CC, CA and AA were 57.8%, 36.4% and 5.8% in gasfric cancer cases, respectively, and 58.2%, 34.9% and 6.9% in controls respectively. The distributions of CDH1 genotypes were not significantly different between gastric cancer cases and controls (P = 0.87 for genotype frequency and P = 0.92 for allele frequency). Compared with the CC genotype, the CA and AA genotypes were not associated with an increased risk for non-cardia gastric cancer (adjusted odds ratios (OR) = 1.15, and 95% confidence interval (95% CI) = 0.78-1.72 for CA genotype, and OR = 0.90 and 95% CI = 0.42-2.01 for AA genotype).

CONCLUSION: E-cadherin gene C-160A promoter polymorphism may not play a major role in the etiology of non-cardia gastric cancer in Chinese population.

Keywords: Gastric cancer; E-cadherin gene; Promoter; Polymorphism