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©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 15, 2004; 10(4): 463-470
Published online Feb 15, 2004. doi: 10.3748/wjg.v10.i4.463
Published online Feb 15, 2004. doi: 10.3748/wjg.v10.i4.463
Roles of main pro- and anti-angiogenic factors in tumor angiogenesis
Zhi Huang, School of Life Sciences, Xiamen University, Xiamen 361005, Fujian Province, China
Shi-Deng Bao, the Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, Fujian Province, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No.30170463
Correspondence to: Zhi Huang, Cell Biology Research Lab, School of Life Sciences, Xiamen University, Xiamen 361005, Fujian Province, China. subhiv@hotmail.com
Telephone: +86-592-2186091 Fax: +86-592-2186091
Received: June 21, 2003
Revised: July 8, 2003
Accepted: July 24, 2003
Published online: February 15, 2004
Revised: July 8, 2003
Accepted: July 24, 2003
Published online: February 15, 2004
Abstract
Tumor growth without size restriction depends on vascular supply. The ability of tumor to induce new blood-vessel formation has been a major focus of cancer research over the past decade. It is now known that members of the vascular endothelial growth factor and angiopoietin families, mainly secreted by tumor cells, induce tumor angiogenesis, whereas other endogenous angiogenic inhibitors, including thrombospondin-1 and angiostatin, keep tumor in dormancy. Experimental and clinical evidence has suggested that the process of tumor metastasis depends on angiogenesis or lymphangiogenesis. This article summarizes the recent research progress for some basic pro- or anti-angiogenic factors in tumor angiogenesis.
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