Tumor necrosis factor &alpha; antibody prevents brain damage of rats with acute necrotizing pancreatitis

doi:10.3748/wjg.v10.i19.2898

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 1, 2004; 10(19): 2898-2900
Published online Oct 1, 2004. doi: 10.3748/wjg.v10.i19.2898

Tumor necrosis factor α antibody prevents brain damage of rats with acute necrotizing pancreatitis

Yan-Ling Yang, Ji-Peng Li, Kai-Zong Li, Ke-Feng Dou

Yan-Ling Yang, Ji-Peng Li, Kai-Zong Li, Ke-Feng Dou, Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Ke-Feng Dou, Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China. gdwk@fmmu.edu.cn

Telephone: +86-29-3375259 Fax: +86-29-3375561

Received: December 12, 2003
Revised: February 13, 2004
Accepted: February 20, 2004
Published online: October 1, 2004

Abstract

AIM: To study the protective effects of tumor necrosis factor α (TNFα ) antibody on pancreatic encephalopathy in rats.

METHODS: One hundred and twenty SD rats were randomly divided into normal control group, acute necrotizing pancreatitis group and TNFα antibody treated group. Acute hemorrhage necrotizing pancreatitis model in rats was induced by retrograde injection of 50 g/L sodium taurocholate into the pancreatobiliary duct. Serum TNFα was detected and animals were killed 12 h after drug administration. Changes in content of brain water, MDA and SOD as well as leucocyte adhesion of brain microvessels were measured.

RESULTS: In TNFα antibody treated group, serum TNFα level was decreased. Content of brain water, MDA and SOD as well as leucocyte adhesion were decreased significantly in comparison with those of acute necrotizing pancreatitis group (P < 0.05).

CONCLUSION: TNFα antibody can alleviate the brain damage of rats with acute hemorrhage necrotizing pancreatitis.

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