Brief Reports
Copyright ©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 15, 2004; 10(18): 2762-2766
Published online Sep 15, 2004. doi: 10.3748/wjg.v10.i18.2762
Effects of Antiadhesion preparation on free fibrinogen and fibrin degrading products in abdominal exudates of rabbits postoperatively
You-Li Wang, Cheng-En Pan, Ping-Lin Yang, Yuan Tian, Shu-Wen Pei, Ming Dong
You-Li Wang, Cheng-En Pan, Department of Hepatobiliary Surgery, Xi’an Jiaotong University First Hospital, Xi’an 710061, Shaanxi Province, China
Ping-Lin Yang, Department of Orthopeadics Surgery, Xi’an Jiaotong University Second hospital, Xi’an 710061, Shaanxi Province, China
Yuan Tian, Shu-Wen Pei, Ming Dong, Department of Gastroenterology, Shaanxi College of TCM Hospital, Xianyang 712000, Shaanxi Province, China
Correspondence to: Dr You-Li Wang, Xi’an Jiaotong University Medical College, Xi’an 710061, Shaanxi Province, China. stage9909@sina.com
Telephone: +86-29-85274659 Fax: +86-29-85323201
Received: December 19, 2003
Revised: December 28, 2003
Accepted: January 15, 2004
Published online: September 15, 2004
Abstract

AIM: To observe effects of ACOL on fibrinogen (FIB), fibrin degrading products (FDP) and changes of FIB and FDP concentration in rabbits with intro-abdominal exudates during 7 d after major abdominal surgery.

METHODS: Sixty New Zealand rabbits were randomly divided into 4 groups: ACOL group, the control group, DCT group and the normal group. After being modeled, except the normal group, the other 3 groups were treated with different ways for a week; the intro-abdominal exudates of rabbits in the 4 groups were drawn for FIB and FDP measurement once daily during 7 d after major abdominal surgery.

RESULTS: FIB and FDP in the intro-abdominal exudates altered in a regular way and ACOL could change the concentration of FIB and FDP in the intra-abdominal exudates after major abdominal surgery.

CONCLUSION: ACOL can prevent intestinal adhesion by reducing the concentration of FIB and raising that of FDP in the intro-abdominal exudates after major abdominal surgery.

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