Brief Reports
Copyright ©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 15, 2004; 10(18): 2759-2761
Published online Sep 15, 2004. doi: 10.3748/wjg.v10.i18.2759
Expression of Survivin in pancreatic cancer and its correlation to expression of Bcl-2
Jian-Guo Qiao, Yu-Qing Zhang, Yu-Chun Yin, Zui Tan
Jian-Guo Qiao, Yu-Chun Yin, Zui Tan, Department of General Surgery, Zhongnan Hospital Affiliated to Wuhan University, Wuhan 430071, Hubei Province, China
Yu-Qing Zhang, Medical Department of Wuhan University, Wuhan 430071, Hubei Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Zui Tan, Department of General Surgery, Zhongnan Hospital Affiliated to Wuhan University, Wuhan 430071, Hubei Province, China. txh728@public.wh.hb.cn
Telephone: +86-27-87325822
Received: October 24, 2003
Revised: December 3, 2003
Accepted: December 22, 2003
Published online: September 15, 2004
Abstract

AIM: To investigate the expression of Survivin in pancreatic cancer and its correlation to the expression of Bcl-2.

METHODS: Survivin and Bcl-2 expressions were examined by immunohistochemistry in 42 tissue samples from pancreatic cancer and 10 from normal pancrease.

RESULTS: No survivin expression was detected in the tissue samples from normal pancrease, while it was detected in 34 of 42 tissue samples from pancreatic cancer (81.95%). There was a correlation between survivin expression and differentiation and stages of pancreatic cancer. Survivin positive cases were strongly correlated to Bcl-2 expression (28/30 vs 6/12, P < 0.05).

CONCLUSION: Overexpression of survivin plays an important role in the development and progression of pancreatic cancer, and correlates to the expression of Bcl-2. Survivin expression can be used as a prognostic factor.

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