Effect of parenteral and enteral nutrition combined with octreotide on pancreatic exocrine secretion of patients with pancreatic fistula

doi:10.3748/wjg.v10.i16.2419

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 15, 2004; 10(16): 2419-2422
Published online Aug 15, 2004. doi: 10.3748/wjg.v10.i16.2419

Effect of parenteral and enteral nutrition combined with octreotide on pancreatic exocrine secretion of patients with pancreatic fistula

Huan-Long Qin, Zhen-Dong Su, Yang Zou, You-Ben Fan

Huan-Long Qin, Zhen-Dong Su, Yang Zou, You-Ben Fan, Department of Surgery, Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, China

Author contributions: All authors contributed equally to the work.

Supported by the Shanghai Science Foundation for Distinguished Young Scholars, No.99QB14010

Correspondence to: Huan-Long Qin, Department of Surgery, Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, China. jiaqc@online.sh.cn

Telephone: +86-21-64368920 Fax: +86-21-64368920

Received: December 10, 2003
Revised: December 22, 2004
Accepted: January 15, 2004
Published online: August 15, 2004

Abstract

AIM: To evaluate the effect of parenteral and enteral nutrition combined with octreotide on pancreatic exocrine secretion of the patients with pancreatic fistula.

METHODS: Pancreatic juice, drained directly from the pancreatic fistula, was collected, and the volume, protein, amylase, HCO₃^-, K⁺, Na⁺ and Cl^- were determined on d 1, 4 and 7 before and after 7-d treatment with octreotide, respectively.

RESULTS: No differences in exocrine pancreatic secretion were observed during the enteral and parenteral nutrition period (t = 2.03, P > 0.05); there were significant decreases in pancreatic juice secretion volume, protein, amylase, HCO₃^-, K⁺, Na⁺ and Cl^- after parenteral and enteral nutrition combined with octreotide compared with octreotide pretreatment (t = 4.14, P < 0.05).

CONCLUSION: There is no stimulatory effect on the pancreatic secretion by intrajejunal nutrition and parenteral nutrition. Octreotide is effective on the reduction of pancreatic fistula output.

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